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Tchem
KDM4D
Lysine-specific demethylase 4D

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335080
  • ENSP00000334181
  • ENSG00000186280
  • ENST00000536741
  • ENSP00000460897
  • ENST00000610872
  • ENSP00000482224

Symbol
  • JHDM3D
  • JMJD2D
  • JMJD2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
biological process
0.55
tissue sample
0.54
cell line
0.52
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.25   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.25   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 66
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0