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Tbio
SCARA3
Scavenger receptor class A member 3

Protein Classes
Protein Summary
Description
Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301904
  • ENSP00000301904
  • ENSG00000168077
  • ENST00000337221
  • ENSP00000337985

Symbol
  • CSR
  • CSR
  • APC7
  • CSR1
  • MSLR1
  • MSRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
transcription factor perturbation
0.68
cellular component
0.67
PubMedID
0.66
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.61   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.61   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
3
93.4
smoking initiation
3
3
3
93
6
3
0
4.8
89.5
family history of Alzheimer’s disease
1
2
0
8.7
83.2
cigarettes per day measurement
3
3
4
75.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
93.4
smoking initiation
3
93
0
4.8
89.5
family history of Alzheimer’s disease
0
8.7
83.2
cigarettes per day measurement
4
75.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class A member 3
VGNC:6573
464076
Macaque
scavenger receptor class A member 3
718263
Mouse
MGI:2444418
219151
Rat
RGD:1309269
364405
Dog
scavenger receptor class A member 3
VGNC:45896
486099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class A member 3
Macaque
scavenger receptor class A member 3
Mouse
Rat
Dog
scavenger receptor class A member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6AZY7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (56)
1 – 10 of 56
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.999999999
p_ni:  1e-9
Score:  0.27
Data Source:  BioPlex,STRINGDB
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.99999901
p_ni:  9.9e-7
Data Source:  BioPlex
SDCCAG8
Tbio
Novelty:  0.0431837
p_int:  0.999997285
p_ni:  0.000002715
Score:  0.209
Data Source:  BioPlex,STRINGDB
INTS6
Tbio
Novelty:  0.02680242
p_int:  0.999944971
p_ni:  0.000055029
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999879645
p_ni:  0.000120355
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999849519
p_ni:  0.000150475
p_wrong:  6e-9
Data Source:  BioPlex
COCH
Tbio
Novelty:  0.00819355
p_int:  0.999546155
p_ni:  0.000453845
Data Source:  BioPlex
HLA-A
Tbio
Novelty:  0.00270731
p_int:  0.997923991
p_ni:  0.002076009
Data Source:  BioPlex
EXTL3
Tbio
Family:  Enzyme
Novelty:  0.00714713
p_int:  0.995155337
p_ni:  0.004844663
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.994539287
p_ni:  0.005460713
Score:  0.248
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  163.61

PubMed score by year
PubTator Score  506.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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