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Tbio
WWC2
Protein WWC2

Protein Summary
Description
This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403733
  • ENSP00000384222
  • ENSG00000151718
  • ENST00000438543
  • ENSP00000413521
  • ENST00000448232
  • ENSP00000398577
  • ENST00000504005
  • ENSP00000427569
  • ENST00000508747
  • ENSP00000420835
  • ENST00000513834
  • ENSP00000425054

Symbol
  • BOMB
  • BOMB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.95
histone modification site profile
0.84
transcription factor binding site profile
0.78
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (38)
1 – 10 of 38
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.99997431
p_ni:  0.000019978
p_wrong:  0.000005712
Score:  0.319
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999580242
p_ni:  0.000419738
p_wrong:  2e-8
Score:  0.216
Data Source:  BioPlex,STRINGDB
LATS2
Tchem
Family:  Kinase
Novelty:  0.00521035
Score:  0.784
Data Source:  STRINGDB
LATS1
Tchem
Family:  Kinase
Novelty:  0.00369058
Score:  0.767
Data Source:  STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
Score:  0.745
Data Source:  STRINGDB
TARBP1
Tbio
Family:  Enzyme
Novelty:  0.04886897
Score:  0.719
Data Source:  STRINGDB
NSUN2
Tbio
Family:  Enzyme
Novelty:  0.01546947
Score:  0.682
Data Source:  STRINGDB
FRMD6
Tbio
Novelty:  0.0034642
Score:  0.68
Data Source:  STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
Score:  0.547
Data Source:  STRINGDB
TEAD1
Tchem
Family:  TF
Novelty:  0.01198524
Score:  0.516
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
63.6
sex hormone-binding globulin measurement
2
1
2
58.4
serum gamma-glutamyl transferase measurement
1
1
1
33.1
aspartate aminotransferase measurement
1
1
0
5.7
24.5
body height
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
63.6
sex hormone-binding globulin measurement
2
58.4
serum gamma-glutamyl transferase measurement
1
33.1
aspartate aminotransferase measurement
0
5.7
24.5
body height
1
15.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW and C2 domain containing 2
VGNC:706
461621
Macaque
WW and C2 domain containing 2
701208
Mouse
MGI:1261872
52357
Rat
RGD:1559427
498630
Dog
WW and C2 domain containing 2
VGNC:48440
482920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW and C2 domain containing 2
Macaque
WW and C2 domain containing 2
Mouse
Rat
Dog
WW and C2 domain containing 2
Publication Statistics
PubMed Score 8.08
PubMed score by year
PubTator Score 34.23
PubTator score by year