Protein Summary
This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]
- ENST00000403733
- ENSP00000384222
- ENSG00000151718
- ENST00000438543
- ENSP00000413521
- ENST00000448232
- ENSP00000398577
- ENST00000504005
- ENSP00000427569
- ENST00000508747
- ENSP00000420835
- ENST00000513834
- ENSP00000425054
- BOMB
- BOMB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
kinase perturbation | 0.95 | ||
histone modification site profile | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.19 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 47 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.19 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 47 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0