You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SLC9A4
Sodium/hydrogen exchanger 4

Protein Summary
Description
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) sec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295269
  • ENSP00000295269
  • ENSG00000180251

Symbol
  • NHE4
  • NHE4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.7
cell type or tissue
0.65
protein domain
0.58
transcription factor
0.49
gene perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.25   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.25   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Proton exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Proton exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (36)
1 – 10 of 36
CHP1
Tbio
Novelty: 0.02100823
Score: 0.881
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00112175
Score: 0.818
Data Source: STRINGDB
RHCG
Tbio
Novelty: 0.00834169
Score: 0.701
Data Source: STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01296563
Score: 0.698
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00331843
Score: 0.675
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.0082907
Score: 0.672
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.02810502
Score: 0.672
Data Source: STRINGDB
RHBG
Tbio
Novelty: 0.02238209
Score: 0.647
Data Source: STRINGDB
SLC12A1
Tclin
Family: Transporter
Novelty: 0.00394411
Score: 0.625
Data Source: STRINGDB
SNAP25
Tclin
Novelty: 0.0020914
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.25

PubMed score by year
PubTator Score  9.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: