Tbio TXNDC8 Thioredoxin domain-containing protein 8

Protein Summary

Description

May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.

Uniprot Accession IDs

• Q6A555
• A1L4I2
• A6NDK7
• Q5T934

Gene Name

• TXNDC8

Ensembl ID

• ENST00000374510
• ENSP00000363634
• ENSG00000204193
• ENST00000374511
• ENSP00000363635

Symbol

• SPTRX3
• TRX6
• TRX6
• SPTRX3
• SPTRX-3
• bA427L11.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.7
gene perturbation	0.59
cell type or tissue	0.54
tissue	0.52
cell line	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.82   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.82   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0