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Tbio
KRT40
Keratin, type I cytoskeletal 40

Protein Summary
Description
May play a role in late hair differentiation. This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377755
  • ENSP00000366984
  • ENSG00000204889
  • ENST00000398486
  • ENSP00000381500
  • ENST00000576967
  • ENSP00000459621
  • ENSG00000262845
  • ENST00000610983
  • ENSP00000479080

Symbol
  • KA36
  • K40
  • KA36
  • CK-40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
cell line
0.61
disease
0.34
biological term
0.33
microRNA
0.32


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (71)
1 – 10 of 71
KRT82
Tdark
Novelty:  0.5488139
Score:  0.925
Data Source:  STRINGDB
KRT85
Tbio
Novelty:  0.09341199
Score:  0.918
Data Source:  STRINGDB
KRT78
Tbio
Novelty:  0.08006367
Score:  0.918
Data Source:  STRINGDB
KRT86
Tbio
Novelty:  0.01021995
Score:  0.917
Data Source:  STRINGDB
KRT72
Tbio
Novelty:  0.06391566
Score:  0.917
Data Source:  STRINGDB
KRT74
Tbio
Novelty:  0.12747273
Score:  0.916
Data Source:  STRINGDB
KRT84
Tdark
Novelty:  0.23563823
Score:  0.916
Data Source:  STRINGDB
KRT80
Tbio
Novelty:  0.08480792
Score:  0.915
Data Source:  STRINGDB
KRT81
Tbio
Novelty:  0.05514238
Score:  0.915
Data Source:  STRINGDB
KRT73
Tdark
Novelty:  0.36334003
Score:  0.915
Data Source:  STRINGDB
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
47.7
1
1
1
47.7
hair shape measurement
1
1
1
5.6
hair shape measurement
1
1
1
5.6
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
47.7
1
47.7
hair shape measurement
1
5.6
hair shape measurement
1
5.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 40
VGNC:12380
454659
Macaque
keratin 40
702950
Mouse
MGI:3629968
406221
Rat
RGD:1359145
287679
Dog
keratin 40
VGNC:42529
608072
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 40
Macaque
keratin 40
Mouse
Rat
Dog
keratin 40
Publication Statistics
PubMed Score 8.91
PubMed score by year
PubTator Score 63.24
PubTator score by year