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Tbio
SPECC1L
Cytospin-A

Protein Summary
Description
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314328
  • ENSP00000325785
  • ENSG00000100014
  • ENST00000437398
  • ENSP00000393363
  • ENST00000541492
  • ENSP00000439633

Symbol
  • CYTSA
  • KIAA0376
  • TBHS
  • CYTSA
  • GBBB2
  • OBLFC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.84
kinase perturbation
0.84
tissue
0.73
drug perturbation
0.71
cell line
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.93   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.93   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
8
8
99.1
monocyte count
2
2
2
93.4
tea consumption measurement
3
3
4
92.2
coffee consumption measurement
4
4
4
90.4
lymphocyte count
2
2
2
83.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
8
99.1
monocyte count
2
93.4
tea consumption measurement
4
92.2
coffee consumption measurement
4
90.4
lymphocyte count
2
83.9
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm antigen with calponin homology and coiled-coil domains 1 like
VGNC:6009
458713
Macaque
sperm antigen with calponin homology and coiled-coil domains 1 like
707641
Mouse
MGI:1921642
74392
Rat
RGD:1309570
361828
Dog
sperm antigen with calponin homology and coiled-coil domains 1 like
486397
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm antigen with calponin homology and coiled-coil domains 1 like
Macaque
sperm antigen with calponin homology and coiled-coil domains 1 like
Mouse
Rat
Dog
sperm antigen with calponin homology and coiled-coil domains 1 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q69YQ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (52)
1 – 10 of 52
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999969578
p_ni:  0.000030422
Score:  0.3
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.99973698
p_ni:  0.00026302
Score:  0.153
Data Source:  BioPlex,STRINGDB
IRAK1BP1
Tbio
Family:  Enzyme
Novelty:  0.02320965
p_int:  0.998511336
p_ni:  0.001488664
Data Source:  BioPlex
VAV1
Tchem
Novelty:  0.00180518
p_int:  0.995856446
p_ni:  0.004143554
Data Source:  BioPlex
AIFM2
Tbio
Novelty:  0.02882373
p_int:  0.994579186
p_ni:  0.005420814
Data Source:  BioPlex
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.994040481
p_ni:  0.005959519
Data Source:  BioPlex
RCN1
Tbio
Novelty:  0.00857135
p_int:  0.984472916
p_ni:  0.015527084
Score:  0.185
Data Source:  BioPlex,STRINGDB
SDHD
Tbio
Family:  Enzyme
Novelty:  0.00167904
p_int:  0.981961659
p_ni:  0.018038341
Data Source:  BioPlex
ATMIN
Tbio
Novelty:  0.07523218
p_int:  0.980708775
p_ni:  0.019291225
Score:  0.216
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.980543842
p_ni:  0.019456158
Data Source:  BioPlex
Publication Statistics
PubMed Score  17.93

PubMed score by year
PubTator Score  4.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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