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Tchem
SLC6A19
Sodium-dependent neutral amino acid transporter B(0)AT1

Protein Summary
Description
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:19185582, PubMed:18484095, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:15286788, PubMed:19185582). Required CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582). This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304460
  • ENSP00000305302
  • ENSG00000174358

Symbol
  • B0AT1
  • HND
  • B0AT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell line
0.58
cellular component
0.48
phenotype
0.48
transcription factor perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.67   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.67   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
nimesulide
Rendered image for nimesulide
Protein-Protein Interactions (69)
1 – 10 of 69
SLC36A2
Tchem
Family:  Transporter
Novelty:  0.01345844
Score:  0.907
Data Source:  STRINGDB
CLTRN
Tbio
Novelty:  0.02711437
Score:  0.823
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.817
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.724
Data Source:  STRINGDB
SLC7A9
Tbio
Family:  Transporter
Novelty:  0.0096383
Score:  0.706
Data Source:  STRINGDB
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
Score:  0.699
Data Source:  STRINGDB
SLC29A3
Tbio
Family:  Transporter
Novelty:  0.01133239
Score:  0.693
Data Source:  STRINGDB
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.685
Data Source:  STRINGDB
ACE2
Tchem
Family:  Enzyme
Novelty:  0.00028408
Score:  0.668
Data Source:  STRINGDB
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
Score:  0.666
Data Source:  STRINGDB
Pathways (15)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Defective SLC6A19 causes Hartnup disorder (HND)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Defective SLC6A19 causes Hartnup disorder (HND)
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
GWAS Traits (72)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
3
7
98.1
mean corpuscular hemoglobin concentration
5
4
5
97.9
neutrophil count
5
5
8
97.7
9
5
0
1.3
97.6
mean corpuscular volume
4
5
6
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
98.1
mean corpuscular hemoglobin concentration
5
97.9
neutrophil count
8
97.7
0
1.3
97.6
mean corpuscular volume
6
97.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 19
VGNC:13591
100612671
Macaque
solute carrier family 6 member 19
100424683
Mouse
MGI:1921588
74338
Rat
RGD:1594328
664630
Dog
solute carrier family 6 member 19
VGNC:46461
100683912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 19
Macaque
solute carrier family 6 member 19
Mouse
Rat
Dog
solute carrier family 6 member 19
Publication Statistics
PubMed Score 69.67
PubMed score by year
PubTator Score 27.89
PubTator score by year