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Tbio
ARHGAP17
Rho GTPase-activating protein 17

Protein Summary
Description
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289968
  • ENSP00000289968
  • ENSG00000140750
  • ENST00000303665
  • ENSP00000303130

Symbol
  • RICH1
  • PP367
  • RICH1
  • WBP15
  • MST066
  • MST110
  • NADRIN
  • PP4534
  • RICH-1
  • MSTP038
  • MSTP066
  • MSTP110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.83
transcription factor binding site profile
0.76
transcription factor perturbation
0.74
kinase perturbation
0.71
cell line
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
1
4
92.7
blood metabolite measurement
1
2
2
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
92.7
blood metabolite measurement
2
77.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 17
VGNC:5675
453999
Mouse
MGI:1917747
70497
Rat
RGD:628767
63994
Dog
Rho GTPase activating protein 17
VGNC:38048
489964
Horse
Rho GTPase activating protein 17
VGNC:15460
100069347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 17
Mouse
Rat
Dog
Rho GTPase activating protein 17
Horse
Rho GTPase activating protein 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q68EM7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (81)
1 – 10 of 81
ARHGAP44
Tbio
Family: Enzyme
Novelty: 0.11113234
p_int: 1
Score: 0.834
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999999994
p_ni: 6e-9
Score: 0.233
Data Source: BioPlex,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
p_int: 0.999999987
p_ni: 1.3e-8
Data Source: BioPlex
PDZK1P1
Tdark
p_int: 0.999999979
p_ni: 2e-8
p_wrong: 1e-9
Data Source: BioPlex
SH3BP1
Tbio
Novelty: 8.50014339
p_int: 0.999999966
p_ni: 3.2e-8
p_wrong: 1e-9
Score: 0.848
Data Source: BioPlex,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
p_int: 0.999997909
p_ni: 0.000002091
Score: 0.785
Data Source: BioPlex,STRINGDB
WDR49
Tdark
Novelty: 1.46160123
p_int: 0.99991815
p_ni: 0.00008185
p_wrong: 1e-9
Score: 0.517
Data Source: BioPlex,STRINGDB
KLC1
Tbio
Novelty: 0.00653484
p_int: 0.998644469
p_ni: 0.001355531
Score: 0.177
Data Source: BioPlex,STRINGDB
GALNT16
Tbio
Family: Enzyme
Novelty: 0.34686672
p_int: 0.997239598
p_ni: 0.002760399
p_wrong: 3e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.34

PubMed score by year
PubTator Score  13.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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