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Tbio
FRMPD2
FERM and PDZ domain-containing protein 2

Protein Summary
Description
May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305531
  • ENSP00000307079
  • ENSG00000170324
  • ENST00000374201
  • ENSP00000363317

Symbol
  • PDZD5C
  • PDZK4
  • PDZK5C
  • PDZK4
  • PDZD5C
  • PDZK5C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.68
cellular component
0.6
cell line
0.47
microRNA
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
7.3
74.6
Myopia
2
2
0
4.2
70.4
age at onset
1
1
0
7.3
58.4
body fat percentage
1
1
1
21.5
body weights and measures
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
7.3
74.6
Myopia
0
4.2
70.4
age at onset
0
7.3
58.4
body fat percentage
1
21.5
body weights and measures
1
17.5
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FERM and PDZ domain containing 2
711199
Cow
FERM and PDZ domain containing 2
VGNC:50131
520665
Pig
FERM and PDZ domain containing 2
100524830
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FERM and PDZ domain containing 2
Cow
FERM and PDZ domain containing 2
Pig
FERM and PDZ domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q68DX3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (35)
1 – 10 of 35
PKN2
Tchem
Family:  Kinase
Novelty:  0.0088412
p_int:  0.998969254
p_ni:  0.001030746
Score:  0.54
Data Source:  BioPlex,STRINGDB
SARS
Tbio
Family:  Enzyme
Novelty:  0.00963508
p_int:  0.932256511
p_ni:  0.067743489
Score:  0.519
Data Source:  BioPlex,STRINGDB
PKP4
Tbio
Novelty:  0.03654703
Score:  0.754
Data Source:  STRINGDB
CTNND2
Tbio
Novelty:  0.01178779
Score:  0.725
Data Source:  STRINGDB
ARVCF
Tbio
Novelty:  0.03248592
Score:  0.72
Data Source:  STRINGDB
KNDC1
Tdark
Novelty:  0.1459108
Score:  0.717
Data Source:  STRINGDB
LRIT1
Tdark
Novelty:  0.77720636
Score:  0.692
Data Source:  STRINGDB
UBTD1
Tdark
Novelty:  0.50393104
Score:  0.651
Data Source:  STRINGDB
FAM160B1
Tdark
Novelty:  0.33441173
Score:  0.646
Data Source:  STRINGDB
SPIRE2
Tbio
Novelty:  0.06697946
Score:  0.644
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.52

PubMed score by year
PubTator Score  2.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer