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Tbio
RNF43
E3 ubiquitin-protein ligase RNF43

Protein Summary
Description
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407977
  • ENSP00000385328
  • ENSG00000108375
  • ENST00000577625
  • ENSP00000463716
  • ENST00000577716
  • ENSP00000462764
  • ENST00000583753
  • ENSP00000462502
  • ENST00000584437
  • ENSP00000463069

Symbol
  • URCC
  • SSPCS
  • RNF124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
transcription factor binding site profile
0.75
transcription factor
0.71
cellular component
0.66
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.57   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.57   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
76
refractive error measurement
1
1
1
69.8
hemoglobin measurement
1
1
1
57.7
intelligence
1
1
0
7.4
47.4
prostate carcinoma
1
1
0
1.1
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
76
refractive error measurement
1
69.8
hemoglobin measurement
1
57.7
intelligence
0
7.4
47.4
prostate carcinoma
0
1.1
18.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
RNF mutants show enhanced WNT signaling and proliferation
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
RNF mutants show enhanced WNT signaling and proliferation
Regulation of FZD by ubiquitination
Signal Transduction
Protein-Protein Interactions (65)
1 – 10 of 65
MYADM
Tbio
Novelty: 0.11475375
p_int: 0.977461933
p_ni: 0.020287403
p_wrong: 0.002250664
Score: 0.187
Data Source: BioPlex,STRINGDB
CSNK1E
Tchem
Family: Kinase
Novelty: 0.00891859
p_int: 0.957167946
p_ni: 0.042832054
Score: 0.177
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.864153911
p_ni: 0.135846089
Score: 0.176
Data Source: BioPlex,STRINGDB
RSPO1
Tbio
Novelty: 0.00365075
Score: 0.998
Data Source: Reactome,STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.992
Data Source: Reactome,STRINGDB
LGR4
Tbio
Family: GPCR
Novelty: 0.01180123
Score: 0.974
Data Source: Reactome,STRINGDB
RSPO2
Tbio
Novelty: 0.0188211
Score: 0.973
Data Source: Reactome,STRINGDB
RSPO3
Tbio
Novelty: 0.02321039
Score: 0.971
Data Source: Reactome,STRINGDB
RSPO4
Tbio
Novelty: 0.05670413
Score: 0.967
Data Source: Reactome,STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.57

PubMed score by year
PubTator Score  52.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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