Tdark USF3 Basic helix-loop-helix domain-containing protein USF3

Protein Summary

Description

Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. This gene encodes a large protein that contains a helix-loop-helix domain and a polyglutamine region. A deletion in the polyglutamine region was associated with risk for thyroid carcinoma. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q68DE3
• Q7Z3L9
• Q8IVF3
• Q9H8T4

Gene Name

• USF3

Ensembl ID

• ENST00000316407
• ENSP00000320794
• ENSG00000176542
• ENST00000478658
• ENSP00000420721

Symbol

• KIAA2018
• KIAA2018

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0