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Tdark
PLA2G4F
Cytosolic phospholipase A2 zeta

Protein Summary
Description
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397272
  • ENSP00000380442
  • ENSG00000168907

Symbol
  • PLA2G4FZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
metabolite
0.78
biological process
0.77
cell line
0.67
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.833
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
PNPLA7
Tdark
Family:  Enzyme
Novelty:  0.11025485
Score:  0.781
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.762
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.756
Data Source:  STRINGDB
ALOX15B
Tchem
Family:  Enzyme
Novelty:  0.01578108
Score:  0.744
Data Source:  STRINGDB
PLA2G15
Tbio
Family:  Enzyme
Novelty:  0.01546393
Score:  0.742
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (152)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685493
271844
Rat
RGD:1593370
691907
Dog
phospholipase A2 group IVF
VGNC:44629
487515
Horse
phospholipase A2 group IVF
VGNC:21516
100071016
Cow
phospholipase A2 group IVF
VGNC:32962
522866
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipase A2 group IVF
Horse
phospholipase A2 group IVF
Cow
phospholipase A2 group IVF
Publication Statistics
PubMed Score 1.02
PubMed score by year
PubTator Score 0.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title