Tbio ANKS6 Ankyrin repeat and SAM domain-containing protein 6

Protein Summary

Description

Required for renal function. This gene encodes a protein containing multiple ankyrin repeats and a SAM domain. It is thought that this protein may localize to the proximal region of the primary cilium, and may play a role in renal and cardiovascular development. Mutations in this gene have been shown to cause a form of nephronophthisis (NPHP16), a chronic tubulo-interstitial nephritis. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q68DC2
• A0SE62
• Q5VSL0
• Q5VSL2
• Q5VSL3
• Q5VSL4
• Q68DB8
• Q6P2R2
• Q8N9L6
• Q96D62

Gene Name

• ANKS6

Ensembl ID

• ENST00000353234
• ENSP00000297837
• ENSG00000165138

Symbol

• ANKRD14
• PKDR1
• SAMD6
• PKDR1
• SAMD6
• NPHP16
• ANKRD14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
protein domain	0.73
tissue sample	0.68
histone modification site profile	0.62
tissue	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.17   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.17   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0