Tbio NCR3LG1 Natural cytotoxicity triggering receptor 3 ligand 1

Protein Summary

Description

Triggers NCR3-dependent natural killer cell activation. B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

Uniprot Accession IDs

• Q68D85
• Q7Z3M6

Gene Name

• NCR3LG1

Ensembl ID

• ENST00000338965
• ENSP00000341637
• ENSG00000188211
• ENST00000530403
• ENSP00000434394

Symbol

• B7H6
• B7H6
• B7-H6
• DKFZp686O24166

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
microRNA	0.78
tissue	0.77
tissue sample	0.72
cell line	0.48

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Natural Cytotoxicity Triggering Receptor 3 Ligand 1

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Natural Cytotoxicity Triggering Receptor 3 Ligand 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Natural Cytotoxicity Triggering Receptor 3 Ligand 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.25   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.25   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

SEC14L1

Tbio

Novelty:  0.09562071

p_int:  0.999997315

p_ni:  0.000002685

Score:  0.185

Data Source:  BioPlex,STRINGDB

RYK

Tbio

Family:  Kinase

Novelty:  0.00910227

p_int:  0.999978944

p_ni:  0.000021056

Score:  0.222

Data Source:  BioPlex,STRINGDB

ARL2

Tbio

Family:  Enzyme

Novelty:  0.01989908

p_int:  0.999926703

p_ni:  0.000071861

p_wrong:  0.000001436

Data Source:  BioPlex

LRBA

Tbio

Novelty:  0.00093369

p_int:  0.999864035

p_ni:  0.000135925

p_wrong:  4e-8

Data Source:  BioPlex

MIGA1

Tbio

Novelty:  0.08346483

p_int:  0.999816019

p_ni:  0.000183981

Data Source:  BioPlex

MMS22L

Tbio

Novelty:  0.22570578

p_int:  0.999739113

p_ni:  0.000260887

Data Source:  BioPlex

DAGLB

Tchem

Family:  Enzyme

Novelty:  0.03269024

p_int:  0.999317426

p_ni:  0.000682574

Data Source:  BioPlex

PODXL

Tbio

Novelty:  0.00306913

p_int:  0.998174982

p_ni:  0.001825018

Score:  0.154

Data Source:  BioPlex,STRINGDB

ATP7A

Tbio

Family:  Enzyme

Novelty:  0.00064155

p_int:  0.997062768

p_ni:  0.002937191

p_wrong:  4.2e-8

Data Source:  BioPlex

FAM171A2

Tdark

Novelty:  1.18763693

p_int:  0.99518693

p_ni:  0.004813006

p_wrong:  6.4e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Immune System	2246 targets	R-HSA-168256
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (2)

Processes (1)

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Items per page:

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1 – 1 of 1

GO Term	Evidence	Assigned by
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (12)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	10	6	2	1.1	97.8
myeloperoxidase measurement	EFO_0005243	1	1	1		78.6
BMI-adjusted waist circumference	EFO_0007789	2	3	3		55.1
sex hormone-binding globulin measurement	EFO_0004696	1	1	1		54.4
body mass index	EFO_0004340	2	3	3		54.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2	1.1	97.8
myeloperoxidase measurement	EFO_0005243	1		78.6
BMI-adjusted waist circumference	EFO_0007789	3		55.1
sex hormone-binding globulin measurement	EFO_0004696	1		54.4
body mass index	EFO_0004340	3		54.4

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UniProt Keyword Find Similar Targets

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3D-structure
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Reference proteome
Repeat
Signal

GWAS Trait Find Similar Targets

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BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body height
body mass index
Drugs used in diabetes use measurement
eosinophil count
glucose tolerance test
HbA1c measurement
myeloperoxidase measurement
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	natural killer cell cytotoxicity receptor 3 ligand 1	VGNC:3095	451055
Dog	natural killer cell cytotoxicity receptor 3 ligand 1	VGNC:52271	102154898

Species	Name	OMA	EggNOG	Inparanoid
Chimp	natural killer cell cytotoxicity receptor 3 ligand 1
Dog	natural killer cell cytotoxicity receptor 3 ligand 1

Publication Statistics

PubMed Score 58.25

PubMed score by year

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PubTator Score 27.17

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (21)

Items per page:

10

0 of 0

PMID	Year	Title