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Tbio
NCR3LG1
Natural cytotoxicity triggering receptor 3 ligand 1

Protein Summary
Description
Triggers NCR3-dependent natural killer cell activation. B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338965
  • ENSP00000341637
  • ENSG00000188211
  • ENST00000530403
  • ENSP00000434394

Symbol
  • B7H6
  • B7H6
  • B7-H6
  • DKFZp686O24166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.78
tissue
0.77
tissue sample
0.72
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.25   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.25   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
SEC14L1
Tbio
Novelty:  0.09562071
p_int:  0.999997315
p_ni:  0.000002685
Score:  0.185
Data Source:  BioPlex,STRINGDB
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.999978944
p_ni:  0.000021056
Score:  0.222
Data Source:  BioPlex,STRINGDB
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999926703
p_ni:  0.000071861
p_wrong:  0.000001436
Data Source:  BioPlex
LRBA
Tbio
Novelty:  0.00093369
p_int:  0.999864035
p_ni:  0.000135925
p_wrong:  4e-8
Data Source:  BioPlex
MIGA1
Tbio
Novelty:  0.08346483
p_int:  0.999816019
p_ni:  0.000183981
Data Source:  BioPlex
MMS22L
Tbio
Novelty:  0.22570578
p_int:  0.999739113
p_ni:  0.000260887
Data Source:  BioPlex
DAGLB
Tchem
Family:  Enzyme
Novelty:  0.03269024
p_int:  0.999317426
p_ni:  0.000682574
Data Source:  BioPlex
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.998174982
p_ni:  0.001825018
Score:  0.154
Data Source:  BioPlex,STRINGDB
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.997062768
p_ni:  0.002937191
p_wrong:  4.2e-8
Data Source:  BioPlex
FAM171A2
Tdark
Novelty:  1.18763693
p_int:  0.99518693
p_ni:  0.004813006
p_wrong:  6.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
6
2
1.1
97.8
myeloperoxidase measurement
1
1
1
78.6
BMI-adjusted waist circumference
2
3
3
55.1
sex hormone-binding globulin measurement
1
1
1
54.4
body mass index
2
3
3
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
97.8
myeloperoxidase measurement
1
78.6
BMI-adjusted waist circumference
3
55.1
sex hormone-binding globulin measurement
1
54.4
body mass index
3
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natural killer cell cytotoxicity receptor 3 ligand 1
VGNC:3095
451055
Dog
natural killer cell cytotoxicity receptor 3 ligand 1
VGNC:52271
102154898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natural killer cell cytotoxicity receptor 3 ligand 1
Dog
natural killer cell cytotoxicity receptor 3 ligand 1
Publication Statistics
PubMed Score 58.25
PubMed score by year
PubTator Score 27.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title