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Tbio
DENND2C
DENN domain-containing protein 2C

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393274
  • ENSP00000376955
  • ENSG00000175984
  • ENST00000393276
  • ENSP00000376957
  • ENST00000393277
  • ENSP00000376958

Symbol
  • dJ1156J9.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
histone modification site profile
0.79
transcription factor binding site profile
0.78
cell type or tissue
0.63
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0