Tbio HAUS3 HAUS augmin-like complex subunit 3

Protein Summary

Description

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q68CZ6
• B4DF64
• O43606
• Q8TAZ5
• Q9BTJ9

Gene Name

• HAUS3

Ensembl ID

• ENST00000243706
• ENSP00000243706
• ENSG00000214367
• ENST00000443786
• ENSP00000392903
• ENST00000506763
• ENSP00000427350

Symbol

• C4orf15
• IT1
• dgt3
• C4orf15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
interacting protein	0.73
tissue	0.66
histone modification site profile	0.64
microRNA	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.61   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.61   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0