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Tbio
TNS3
Tensin-3

Protein Summary
Description
May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311160
  • ENSP00000312143
  • ENSG00000136205
  • ENST00000442536
  • ENSP00000389285
  • ENST00000458317
  • ENSP00000388318

Symbol
  • TEM6
  • TENS1
  • TPP
  • TEM6
  • TENS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
protein domain
0.97
virus perturbation
0.9
PubMedID
0.86
cell type or tissue
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.91   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.91   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
4
4
90.5
myeloid white cell count
2
2
2
74.4
reticulocyte count
4
3
4
72.8
3
3
1
1.1
68.3
neutrophil count
2
2
2
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
4
90.5
myeloid white cell count
2
74.4
reticulocyte count
4
72.8
1
1.1
68.3
neutrophil count
2
66.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tensin 3
VGNC:4547
463400
Macaque
tensin 3
700541
Mouse
MGI:2443012
319939
Rat
RGD:1564174
360980
Dog
tensin 3
VGNC:51833
491620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tensin 3
Macaque
tensin 3
Mouse
Rat
Dog
tensin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q68CZ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
MET interacts with TNS proteins (R-HSA-8875513)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET interacts with TNS proteins
Reactome
MET promotes cell motility
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET interacts with TNS proteins
MET promotes cell motility
Signal Transduction
Signaling by MET
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (60)
1 – 10 of 60
DLC1
Tbio
Family:  Enzyme
Novelty:  0.00819701
Score:  0.951
Data Source:  STRINGDB
MET
Tclin
Family:  Kinase
Novelty:  0.00037995
Score:  0.921
Data Source:  Reactome,STRINGDB
HGF
Tchem
Family:  Enzyme
Novelty:  0.00035574
Score:  0.906
Data Source:  Reactome,STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.88
Data Source:  STRINGDB
STARD13
Tbio
Novelty:  0.00750938
Score:  0.804
Data Source:  STRINGDB
STARD8
Tbio
Novelty:  0.03759193
Score:  0.804
Data Source:  STRINGDB
ARHGAP40
Tdark
Family:  Enzyme
Novelty:  4.12645161
Score:  0.739
Data Source:  STRINGDB
ARHGAP28
Tdark
Family:  Enzyme
Novelty:  0.33612416
Score:  0.739
Data Source:  STRINGDB
ARHGAP18
Tbio
Family:  Enzyme
Novelty:  0.10618156
Score:  0.739
Data Source:  STRINGDB
PLXDC1
Tbio
Novelty:  0.01025354
Score:  0.705
Data Source:  STRINGDB
Publication Statistics
PubMed Score  67.91

PubMed score by year
PubTator Score  30.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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