You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARID2
AT-rich interactive domain-containing protein 2

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by Ref ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.9
protein domain
0.85
cell line
0.79
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.32   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.32   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999999144
p_ni:  8.55e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999998582
p_ni:  0.000001417
p_wrong:  1e-9
Score:  0.854
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999996389
p_ni:  0.000003611
Score:  0.987
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.999996356
p_ni:  0.000003644
Score:  0.993
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999994767
p_ni:  0.000005231
p_wrong:  3e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999961312
p_ni:  0.000038687
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999930425
p_ni:  0.000069574
p_wrong:  1e-9
Score:  0.539
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999891678
p_ni:  0.000099354
p_wrong:  0.000008968
Score:  0.803
Data Source:  BioPlex,STRINGDB
SS18
Tbio
Novelty:  0.00915548
p_int:  0.996461114
p_ni:  0.003538886
Score:  0.898
Data Source:  BioPlex,STRINGDB
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
p_int:  0.894612868
p_ni:  0.105386126
p_wrong:  0.000001006
Score:  0.219
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
85.2
chronotype measurement
3
3
2
1
83.8
red blood cell density measurement
1
1
1
76.9
hemoglobin measurement
2
2
2
71.1
sex hormone-binding globulin measurement
3
2
3
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
85.2
chronotype measurement
2
1
83.8
red blood cell density measurement
1
76.9
hemoglobin measurement
2
71.1
sex hormone-binding globulin measurement
3
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 2
VGNC:4933
451847
Macaque
AT-rich interaction domain 2
703823
Mouse
MGI:1924294
77044
Rat
RGD:1311105
366980
Dog
AT-rich interaction domain 2
VGNC:38094
100688573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 2
Macaque
AT-rich interaction domain 2
Mouse
Rat
Dog
AT-rich interaction domain 2
Publication Statistics
PubMed Score 61.32
PubMed score by year
PubTator Score 265.10
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title