Tbio ARID2 AT-rich interactive domain-containing protein 2

Protein Summary

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q68CP9
• Q15KG9
• Q5EB51
• Q645I3
• Q6ZRY5
• Q7Z3I5
• Q86T28
• Q96SJ6
• Q9HCL5
• ARID domain-containing protein 2

Gene Name

• ARID2

Ensembl ID

• ENST00000334344
• ENSP00000335044
• ENSG00000189079

Symbol

• BAF200
• KIAA1557
• CSS6
• p200
• BAF200

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor binding site profile	0.9
protein domain	0.85
cell line	0.79
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.69   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.69   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0