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Tdark
TPGS2
Tubulin polyglutamylase complex subunit 2

Protein Summary
Description
This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334295
  • ENSP00000335144
  • ENSG00000134779
  • ENST00000383056
  • ENSP00000372530
  • ENST00000589049
  • ENSP00000466973
  • ENST00000590842
  • ENSP00000464780
  • ENST00000593035
  • ENSP00000467392

Symbol
  • C18orf10
  • L17
  • PGs2
  • C18orf10
  • HMFN0601
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor perturbation
0.96
histone modification site profile
0.91
kinase perturbation
0.66
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
2
87.1
heel bone mineral density
2
1
2
52.7
1
1
0
1.1
30.2
reaction time measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
87.1
heel bone mineral density
2
52.7
0
1.1
30.2
reaction time measurement
1
14.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin polyglutamylase complex subunit 2
VGNC:5214
455380
Macaque
tubulin polyglutamylase complex subunit 2
709953
Mouse
MGI:1913898
66648
Rat
RGD:1310571
361301
Dog
tubulin polyglutamylase complex subunit 2
VGNC:47737
480156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin polyglutamylase complex subunit 2
Macaque
tubulin polyglutamylase complex subunit 2
Mouse
Rat
Dog
tubulin polyglutamylase complex subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q68CL5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (27)
1 – 10 of 27
NICN1
Tdark
Novelty:  0.32909597
p_int:  0.999999895
p_ni:  9.9e-8
p_wrong:  6e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
LRRC49
Tdark
Novelty:  0.19477281
p_int:  0.999889611
p_ni:  0.000110389
Score:  0.981
Data Source:  BioPlex,STRINGDB
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
p_int:  0.999769401
p_ni:  0.000230595
p_wrong:  4e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
C11orf49
Tdark
Novelty:  2.11371852
p_int:  0.999449756
p_ni:  0.000549599
p_wrong:  6.45e-7
Score:  0.857
Data Source:  BioPlex,STRINGDB
GRAPL
Tdark
Novelty:  2.61452514
p_int:  0.993890766
p_ni:  0.00596213
p_wrong:  0.000147104
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.983346882
p_ni:  0.016653118
Data Source:  BioPlex
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.882166076
p_ni:  0.117833924
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.763187302
p_ni:  0.236812698
Score:  0.166
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.752581966
p_ni:  0.247418034
Data Source:  BioPlex
TPGS1
Tdark
Family:  Enzyme
Novelty:  0.38252921
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.11

PubMed score by year
PubTator Score  4.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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