Tdark ACSM2B Acyl-coenzyme A synthetase ACSM2B, mitochondrial

Protein Summary

Description

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

Uniprot Accession IDs

• Q68CK6
• Q86YT1

Gene Name

• ACSM2B

Ensembl ID

• ENST00000329697
• ENSP00000327453
• ENSG00000066813
• ENST00000414188
• ENSP00000390378
• ENST00000565232
• ENSP00000454995
• ENST00000567001
• ENSP00000456378

Symbol

• ACSM2
• HXMA
• ACSM2
• HYST1046

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
pathway	0.72
cell line	0.69
cellular component	0.5
metabolite	0.46

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Acyl-coenzyme A Synthetase Acsm2b, Mitochondrial

Protein / Ligase / Acyl-coenzyme A Synthetase Acsm2b, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Acyl-coenzyme A Synthetase Acsm2b, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 4   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (16)

Explore Interacting Targets

1 – 10 of 16

• See Interactions on String-DB

ACADS

Tbio

Family:  Enzyme

Novelty:  0.00841051

Score:  0.926

Data Source:  STRINGDB

PALMD

Tbio

Novelty:  0.11193793

Score:  0.638

Data Source:  STRINGDB

ACOT4

Tbio

Family:  Enzyme

Novelty:  0.13441184

Score:  0.533

Data Source:  STRINGDB

RETSAT

Tdark

Family:  Enzyme

Novelty:  0.10624626

Score:  0.516

Data Source:  STRINGDB

CS

Tbio

Family:  Enzyme

Novelty:  0.00154214

Score:  0.498

Data Source:  STRINGDB

RNMT

Tbio

Family:  Enzyme

Novelty:  0.00880207

Score:  0.488

Data Source:  STRINGDB

ACOT2

Tbio

Family:  Enzyme

Novelty:  0.03086222

Score:  0.458

Data Source:  STRINGDB

ACSBG1

Tbio

Family:  Enzyme

Novelty:  0.00381436

Score:  0.458

Data Source:  STRINGDB

ACSL4

Tbio

Family:  Enzyme

Novelty:  0.0072645

Score:  0.455

Data Source:  STRINGDB

CRAT

Tbio

Family:  Enzyme

Novelty:  0.01242609

Score:  0.441

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (8)

KEGG (2)

Amino Acid conjugation (R-HSA-156587)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amino Acid conjugation	9 targets	R-HSA-156587
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Conjugation of benzoate with glycine	6 targets	R-HSA-177135
Reactome	Conjugation of carboxylic acids	9 targets	R-HSA-159424
Reactome	Conjugation of phenylacetate with glutamine	2 targets	R-HSA-177162

Name	Explore in Pharos	Explore in Source
Amino Acid conjugation	9 targets	R-HSA-156587
Biological oxidations	221 targets	R-HSA-211859
Conjugation of benzoate with glycine	6 targets	R-HSA-177135
Conjugation of carboxylic acids	9 targets	R-HSA-159424
Conjugation of phenylacetate with glutamine	2 targets	R-HSA-177162

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (7)

Components (2)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
acyl-CoA ligase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
fatty acid ligase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
fatty-acyl-CoA synthase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
CoA-ligase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
butyrate-CoA ligase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	1	3	3		91.7
serum metabolite measurement	EFO_0005653	1	1	1		46.5
sleep duration	EFO_0005271	1	1	1		38.8
triglyceride measurement	EFO_0004530	1	1	1		38.8
creatinine measurement	EFO_0004518	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	3		91.7
serum metabolite measurement	EFO_0005653	1		46.5
sleep duration	EFO_0005271	1		38.8
triglyceride measurement	EFO_0004530	1		38.8
creatinine measurement	EFO_0004518	1		30.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
ATP-binding
Complete proteome
Direct protein sequencing
Fatty acid metabolism
Ligase
Lipid metabolism
Magnesium
Metal-binding
Mitochondrion
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
creatinine measurement
gout
serum metabolite measurement
sleep duration
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
integument phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 12.71

PubMed score by year

Reset Zoom

PubTator Score 4.50

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (13)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title