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Tdark
ACSM2B
Acyl-coenzyme A synthetase ACSM2B, mitochondrial

Protein Summary
Description
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329697
  • ENSP00000327453
  • ENSG00000066813
  • ENST00000414188
  • ENSP00000390378
  • ENST00000565232
  • ENSP00000454995
  • ENST00000567001
  • ENSP00000456378

Symbol
  • ACSM2
  • HXMA
  • ACSM2
  • HYST1046
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
pathway
0.72
cell line
0.69
cellular component
0.5
metabolite
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
Score:  0.926
Data Source:  STRINGDB
PALMD
Tbio
Novelty:  0.11193793
Score:  0.638
Data Source:  STRINGDB
ACOT4
Tbio
Family:  Enzyme
Novelty:  0.13441184
Score:  0.533
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.516
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.498
Data Source:  STRINGDB
RNMT
Tbio
Family:  Enzyme
Novelty:  0.00880207
Score:  0.488
Data Source:  STRINGDB
ACOT2
Tbio
Family:  Enzyme
Novelty:  0.03086222
Score:  0.458
Data Source:  STRINGDB
ACSBG1
Tbio
Family:  Enzyme
Novelty:  0.00381436
Score:  0.458
Data Source:  STRINGDB
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
Score:  0.455
Data Source:  STRINGDB
CRAT
Tbio
Family:  Enzyme
Novelty:  0.01242609
Score:  0.441
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Amino Acid conjugation (R-HSA-156587)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino Acid conjugation
Reactome
Biological oxidations
Reactome
Conjugation of benzoate with glycine
Reactome
Conjugation of carboxylic acids
Reactome
Conjugation of phenylacetate with glutamine
Name
Explore in Pharos
Explore in Source
Amino Acid conjugation
Biological oxidations
Conjugation of benzoate with glycine
Conjugation of carboxylic acids
Conjugation of phenylacetate with glutamine
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
3
3
91.7
serum metabolite measurement
1
1
1
46.5
sleep duration
1
1
1
38.8
triglyceride measurement
1
1
1
38.8
creatinine measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.7
serum metabolite measurement
1
46.5
sleep duration
1
38.8
triglyceride measurement
1
38.8
creatinine measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 12.71
PubMed score by year
PubTator Score 4.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title