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Tbio
CREB3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

Protein Summary
Description
Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing resu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000078445
  • ENSP00000078445
  • ENSG00000060566
  • ENST00000595923
  • ENSP00000469355
  • ENST00000602147
  • ENSP00000470119
  • ENST00000602257
  • ENSP00000472399

Symbol
  • CREBH
  • CREBH
  • CREB-H
  • HYST1481
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
biological process
0.66
gene perturbation
0.65
cellular component
0.57
cell type or tissue
0.55


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.03   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.03   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cAMP responsive element binding protein 3 like 3
VGNC:11991
468672
Macaque
cyclic AMP-responsive element-binding protein 3-like protein 3
721825
Mouse
MGI:2384786
208677
Rat
RGD:1308152
314638
Dog
cAMP responsive element binding protein 3 like 3
VGNC:54593
485046
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cAMP responsive element binding protein 3 like 3
Macaque
cyclic AMP-responsive element-binding protein 3-like protein 3
Mouse
Rat
Dog
cAMP responsive element binding protein 3 like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q68CJ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (52)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
CREB3 factors activate genes
Reactome
Metabolism of proteins
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
CREB3 factors activate genes
Metabolism of proteins
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (104)
1 – 10 of 104
APOA4
Tbio
Novelty: 0.00305835
Score: 0.981
Data Source: STRINGDB
APOA5
Tbio
Novelty: 0.00232222
Score: 0.973
Data Source: STRINGDB
MBTPS2
Tbio
Family: Enzyme
Novelty: 0.00625665
Score: 0.969
Data Source: Reactome,STRINGDB
APOC2
Tbio
Novelty: 0.0015496
Score: 0.968
Data Source: STRINGDB
MBTPS1
Tchem
Family: Enzyme
Novelty: 0.00845881
Score: 0.965
Data Source: Reactome,STRINGDB
FGF21
Tbio
Novelty: 0.00111728
Score: 0.952
Data Source: STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.948
Data Source: STRINGDB
CREB3L1
Tbio
Family: TF
Novelty: 0.02295608
Score: 0.928
Data Source: STRINGDB
CREB3
Tbio
Family: TF
Novelty: 0.00424318
Score: 0.922
Data Source: STRINGDB
HAMP
Tbio
Novelty: 0.00035828
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.03

PubMed score by year
PubTator Score  17.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer