Tbio MUC17 Mucin-17

Protein Summary

Description

Probably plays a role in maintaining homeostasis on mucosal surfaces. The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q685J3
• O14761
• Q685J2
• Q8TDH7
• MUC-17

Gene Name

• MUC17

Ensembl ID

• ENST00000306151
• ENSP00000302716
• ENSG00000169876

Symbol

• MUC3
• MUC3
• MUC-3
• MUC-17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.63
cell line	0.56
cellular component	0.55
cell type or tissue	0.44
biological term	0.42

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
plasminogen activator inhibitor 1 measurement	EFO_0004792	1	1	1		38.7
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		38.2
body height	EFO_0004339	1	1	1		31.4
chronic kidney disease	EFO_0003884	1	1	0	3.4	21.5
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		12.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
plasminogen activator inhibitor 1 measurement	EFO_0004792	1		38.7
apolipoprotein A 1 measurement	EFO_0004614	1		38.2
body height	EFO_0004339	1		31.4
chronic kidney disease	EFO_0003884	0	3.4	21.5
low density lipoprotein cholesterol measurement	EFO_0004611	1		12.9

Reset Zoom  Beta Count   Odds Ratio

Protein Structure (0 Structures, 17 AlphaFold Models)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q685J3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (11)

Functions (2)

Components (6)

Processes (3)

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1 – 2 of 2

GO Term	Evidence	Assigned by
PDZ domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
extracellular matrix constituent, lubricant activity	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL

Protein-Protein Interactions (75)

Explore Interacting Targets

1 – 10 of 75

• See Interactions on String-DB

MUC13

Tbio

Novelty:  0.01282861

Score:  0.98

Data Source:  STRINGDB

MUC15

Tbio

Novelty:  0.02213624

Score:  0.978

Data Source:  STRINGDB

MUC20

Tbio

Novelty:  0.04645313

Score:  0.972

Data Source:  STRINGDB

MUC6

Tbio

Novelty:  0.00304872

Score:  0.972

Data Source:  STRINGDB

MUC16

Tbio

Novelty:  0.00444587

Score:  0.972

Data Source:  STRINGDB

MUC7

Tbio

Novelty:  0.00750654

Score:  0.971

Data Source:  STRINGDB

MUC5B

Tbio

Novelty:  0.000832

Score:  0.97

Data Source:  STRINGDB

MUC5AC

Tbio

Novelty:  0.00074159

Score:  0.97

Data Source:  STRINGDB

MUC21

Tbio

Novelty:  0.02583488

Score:  0.969

Data Source:  STRINGDB

MUC1

Tchem

Novelty:  0.00024203

Score:  0.966

Data Source:  STRINGDB

Publication Statistics

PubMed Score  33.06

PubMed score by year

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PubTator Score  20.87

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
body height
chronic kidney disease
low density lipoprotein cholesterol measurement
plasminogen activator inhibitor 1 measurement
smoking status measurement
total cholesterol measurement