Protein Summary
Probably plays a role in maintaining homeostasis on mucosal surfaces. The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
- ENST00000306151
- ENSP00000302716
- ENSG00000169876
- MUC3
- MUC3
- MUC-3
- MUC-17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.63 | ||
cell line | 0.56 | ||
cellular component | 0.55 | ||
cell type or tissue | 0.44 | ||
biological term | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.06 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 54 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.06 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 54 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
Nearest Tclin Targets
Pathways (15)
Reactome (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Reactome | Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
plasminogen activator inhibitor 1 measurement | 1 | 1 | 1 | 38.7 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 38.2 | |||||
body height | 1 | 1 | 1 | 31.4 | |||||
1 | 1 | 0 | 3.4 | 21.5 | |||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 12.9 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
plasminogen activator inhibitor 1 measurement | 1 | 38.7 | |||||
apolipoprotein A 1 measurement | 1 | 38.2 | |||||
body height | 1 | 31.4 | |||||
0 | 3.4 | 21.5 | |||||
low density lipoprotein cholesterol measurement | 1 | 12.9 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 33.06
PubMed score by year
PubTator Score 20.87
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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