Tbio ATG16L1 Autophagy-related protein 16-1

Protein Summary

Description

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q676U5
• A3EXK9
• A3EXL0
• B6ZDH0
• Q6IPN1
• Q6UXW4
• Q6ZVZ5
• Q8NCY2
• Q96JV5
• Q9H619

Gene Name

• ATG16L1

Ensembl ID

• ENST00000347464
• ENSP00000318259
• ENSG00000085978
• ENST00000373525
• ENSP00000362625
• ENST00000392017
• ENSP00000375872
• ENST00000392020
• ENSP00000375875
• ENST00000625501
• ENSP00000487542
• ENSG00000281089
• ENST00000626623
• ENSP00000487298
• ENST00000630066
• ENSP00000487446
• ENST00000630204
• ENSP00000487455

Symbol

• APG16L
• IBD10
• WDR30
• APG16L
• ATG16A
• ATG16L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor binding site profile	0.95
protein domain	0.85
interacting protein	0.76
hub protein	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.96   (req: < 5)

Gene RIFs: 190   (req: <= 3)

Antibodies: 773   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.96   (req: >= 5)

Gene RIFs: 190   (req: > 3)

Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0