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Tbio
ATG16L1
Autophagy-related protein 16-1

Protein Summary
Description
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a ca ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347464
  • ENSP00000318259
  • ENSG00000085978
  • ENST00000373525
  • ENSP00000362625
  • ENST00000392017
  • ENSP00000375872
  • ENST00000392020
  • ENSP00000375875
  • ENST00000625501
  • ENSP00000487542
  • ENSG00000281089
  • ENST00000626623
  • ENSP00000487298
  • ENST00000630066
  • ENSP00000487446
  • ENST00000630204
  • ENSP00000487455

Symbol
  • APG16L
  • IBD10
  • WDR30
  • APG16L
  • ATG16A
  • ATG16L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor binding site profile
0.95
protein domain
0.85
interacting protein
0.76
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.53   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 773   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.53   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
5
0
1.3
99.6
7
5
0
1.3
99.6
bilirubin measurement
3
2
3
96
bilirubin measurement
3
2
3
96
1
1
0
1.1
84.1
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
99.6
0
1.3
99.6
bilirubin measurement
3
96
bilirubin measurement
3
96
0
1.1
84.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 16 like 1
VGNC:10577
460022
Macaque
autophagy related 16 like 1
714092
Mouse
MGI:1924290
77040
Rat
RGD:1310631
363278
Dog
autophagy related 16 like 1
VGNC:38219
477412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 16 like 1
Macaque
autophagy related 16 like 1
Mouse
Rat
Dog
autophagy related 16 like 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q676U5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Protein-Protein Interactions (144)
1 – 10 of 144
ATG3
Tbio
Novelty: 0.00541077
p_int: 0.999999981
p_ni: 1.7e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
WIPI2
Tbio
Novelty: 0.02685992
p_int: 0.999997706
p_ni: 0.000002294
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
RAB33B
Tbio
Family: Enzyme
Novelty: 0.06381712
p_int: 0.999992914
p_ni: 0.000007086
Score: 0.976
Data Source: BioPlex,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999970906
p_ni: 0.000029094
Data Source: BioPlex
SCOC
Tbio
Novelty: 0.05277646
p_int: 0.999800231
p_ni: 0.000199759
p_wrong: 1e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 0.999422533
p_ni: 0.000577464
p_wrong: 3e-9
Data Source: BioPlex
SPC25
Tbio
Novelty: 0.26354244
p_int: 0.985969879
p_ni: 0.014017631
p_wrong: 0.000012489
Score: 0.51
Data Source: BioPlex,STRINGDB
COLEC12
Tbio
Novelty: 0.02882427
p_int: 0.98346148
p_ni: 0.01167172
p_wrong: 0.004866801
Score: 0.239
Data Source: BioPlex,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.959560565
p_ni: 0.040402431
p_wrong: 0.000037004
Data Source: BioPlex
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.871245692
p_ni: 0.128754308
Data Source: BioPlex
Publication Statistics
PubMed Score  334.53

PubMed score by year
PubTator Score  171.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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