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Tbio
KAZN
Kazrin

Protein Summary
Description
Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361144
  • ENSP00000354727
  • ENSG00000189337
  • ENST00000376030
  • ENSP00000365198
  • ENST00000400797
  • ENSP00000383601
  • ENST00000400798
  • ENSP00000383602
  • ENST00000503743
  • ENSP00000426015

Symbol
  • KAZ
  • KIAA1026
  • KAZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
transcription factor perturbation
0.84
microRNA
0.81
transcription factor
0.72
gene perturbation
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
68.4
1
1
0
4.8
55.6
1
1
0
1.2
54.5
urinary albumin to creatinine ratio
1
1
1
24.8
1
1
1
24.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
68.4
0
4.8
55.6
0
1.2
54.5
urinary albumin to creatinine ratio
1
24.8
1
24.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kazrin, periplakin interacting protein
VGNC:11465
456454
Macaque
kazrin, periplakin interacting protein
100428292
Mouse
MGI:1918779
71529
Rat
RGD:1359147
313672
Dog
kazrin, periplakin interacting protein
VGNC:42221
607338
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kazrin, periplakin interacting protein
Macaque
kazrin, periplakin interacting protein
Mouse
Rat
Dog
kazrin, periplakin interacting protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q674X7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (7)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (22)
1 – 10 of 22
PPL
Tbio
Novelty: 0.00684645
Score: 0.983
Data Source: Reactome,STRINGDB
ARVCF
Tbio
Novelty: 0.03248592
Score: 0.719
Data Source: STRINGDB
PKP1
Tbio
Novelty: 0.0100609
Score: 0.688
Data Source: STRINGDB
EVPL
Tbio
Novelty: 0.00274279
Score: 0.676
Data Source: STRINGDB
ARHGAP5
Tbio
Family: Enzyme
Novelty: 0.03683127
Score: 0.671
Data Source: STRINGDB
PKP4
Tbio
Novelty: 0.03654703
Score: 0.586
Data Source: STRINGDB
ARMC4
Tbio
Novelty: 0.17860406
Score: 0.583
Data Source: STRINGDB
PKP3
Tbio
Novelty: 0.0269462
Score: 0.578
Data Source: STRINGDB
ARMC3
Tbio
Novelty: 0.09818374
Score: 0.562
Data Source: STRINGDB
SLC35G1
Tbio
Family: Transporter
Novelty: 0.06448845
Score: 0.544
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.26

PubMed score by year
PubTator Score  6.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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