Tbio KAZN Kazrin

Protein Summary

Description

Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q674X7
• B0QYQ0
• B1AK78
• Q5TGF1
• Q674X4
• Q674X6
• Q6ZUD1
• Q8IYN7
• Q8N409
• Q9UIL2
• Q9UPX4

Gene Name

• KAZN

Ensembl ID

• ENST00000361144
• ENSP00000354727
• ENSG00000189337
• ENST00000376030
• ENSP00000365198
• ENST00000400797
• ENSP00000383601
• ENST00000400798
• ENSP00000383602
• ENST00000503743
• ENSP00000426015

Symbol

• KAZ
• KIAA1026
• KAZ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
transcription factor perturbation	0.84
microRNA	0.81
transcription factor	0.72
gene perturbation	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.11   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.11   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0