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Tbio
PPP2R2D
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Protein Summary
Description
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000455566
  • ENSP00000399970
  • ENSG00000175470

Symbol
  • KIAA1541
  • B55D
  • MDS026
  • B55delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
virus perturbation
0.76
protein domain
0.73
tissue sample
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.76   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.76   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
93.3
C-reactive protein measurement
1
1
1
86
intelligence
2
2
1
5.6
69.2
self reported educational attainment
2
1
2
61.7
systolic blood pressure
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
93.3
C-reactive protein measurement
1
86
intelligence
1
5.6
69.2
self reported educational attainment
2
61.7
systolic blood pressure
1
46
Pathways (47)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
MASTL Facilitates Mitotic Progression
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
M Phase
MASTL Facilitates Mitotic Progression
Mitotic Prophase
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (210)
1 – 10 of 210
CDCA4
Tbio
Novelty: 0.04549061
p_int: 1
Score: 0.54
Data Source: BioPlex,STRINGDB
IER2
Tbio
Novelty: 0.03864806
p_int: 0.999999996
p_ni: 4e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
p_int: 0.999999918
p_ni: 8.1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
SGO2
Tbio
Novelty: 0.05544423
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.541
Data Source: BioPlex,STRINGDB
SERTAD4
Tdark
Novelty: 0.70786986
p_int: 0.999999792
p_ni: 2.08e-7
Score: 0.668
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999999783
p_ni: 2.17e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
PPME1
Tchem
Family: Enzyme
Novelty: 0.01559862
p_int: 0.999999718
p_ni: 2.82e-7
Score: 0.724
Data Source: BioPlex,STRINGDB
FAM122A
Tbio
Novelty: 0.3107759
p_int: 0.999999591
p_ni: 4.09e-7
Data Source: BioPlex
COP1
Tbio
Family: Enzyme
Novelty: 0.10908534
p_int: 0.99999155
p_ni: 0.00000845
Score: 0.189
Data Source: BioPlex,STRINGDB
RBM7
Tbio
Novelty: 0.07482689
p_int: 0.999990905
p_ni: 0.000009095
Score: 0.351
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.76

PubMed score by year
PubTator Score  6.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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