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Tbio
CPZ
Carboxypeptidase Z

Protein Summary
Description
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315782
  • ENSP00000315074
  • ENSG00000109625
  • ENST00000360986
  • ENSP00000354255
  • ENST00000382480
  • ENSP00000371920
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
cell type or tissue
0.72
PubMedID
0.66
protein domain
0.58
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 980.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 980.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
70.2
body height
1
1
1
57.1
body fat distribution
1
1
2
42.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
70.2
body height
1
57.1
body fat distribution
2
42.2
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (34)
1 – 10 of 34
L3HYPDH
Tdark
Family: Enzyme
Novelty: 0.35456591
p_int: 0.999428964
p_ni: 0.000571036
Score: 0.282
Data Source: BioPlex,STRINGDB
BAG1
Tbio
Novelty: 0.00285515
p_int: 0.946968472
p_ni: 0.048471215
p_wrong: 0.004560312
Score: 0.28
Data Source: BioPlex,STRINGDB
AFF1
Tbio
Family: TF
Novelty: 0.00094358
Score: 0.86
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.716
Data Source: STRINGDB
PCSK2
Tchem
Family: Enzyme
Novelty: 0.00611421
Score: 0.71
Data Source: STRINGDB
GSN
Tbio
Novelty: 0.00060852
Score: 0.705
Data Source: STRINGDB
RTN4
Tbio
Novelty: 0.00080371
Score: 0.685
Data Source: STRINGDB
PLXNA2
Tbio
Novelty: 0.01765957
Score: 0.663
Data Source: STRINGDB
PLK4
Tchem
Family: Kinase
Novelty: 0.00265851
Score: 0.65
Data Source: STRINGDB
TNPO3
Tbio
Novelty: 0.01709028
Score: 0.624
Data Source: STRINGDB
Publication Statistics
PubMed Score  980.30

PubMed score by year
PubTator Score  25.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer