You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAP1S
Microtubule-associated protein 1S

Protein Summary
Description
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324096
  • ENSP00000325313
  • ENSG00000130479
  • ENST00000544059
  • ENSP00000439243

Symbol
  • BPY2IP1
  • C19orf5
  • MAP8
  • VCY2IP1
  • MAP8
  • BPY2IP1
  • C19orf5
  • VCY2IP1
  • VCY2IP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
cellular component
0.88
kinase
0.79
hub protein
0.75
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.74   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.74   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
RASSF1
Tbio
Novelty:  0.00137149
p_int:  0.999997782
p_ni:  0.000002218
Score:  0.829
Data Source:  BioPlex,STRINGDB
NOXO1
Tbio
Family:  Enzyme
Novelty:  0.02648748
p_int:  0.999994521
p_ni:  0.000005479
Data Source:  BioPlex
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.999924157
p_ni:  0.000075843
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999918522
p_ni:  0.000081478
Data Source:  BioPlex
DBF4B
Tbio
Novelty:  0.48127081
p_int:  0.999797287
p_ni:  0.000202713
Score:  0.295
Data Source:  BioPlex,STRINGDB
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.994522494
p_ni:  0.005477506
Score:  0.183
Data Source:  BioPlex,STRINGDB
FAS
Tbio
Novelty:  0.00043286
p_int:  0.967084051
p_ni:  0.032915948
p_wrong:  2e-9
Data Source:  BioPlex
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.961961879
p_ni:  0.038038112
p_wrong:  8e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
ATG3
Tbio
Novelty:  0.00541077
p_int:  0.94438597
p_ni:  0.05561403
Score:  0.331
Data Source:  BioPlex,STRINGDB
LIPH
Tbio
Family:  Enzyme
Novelty:  0.00961658
p_int:  0.907669776
p_ni:  0.092330224
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
83.1
4
3
4
76.7
5
2
0
1.2
75.4
cancer antigen 19.9 measurement
1
1
1
57.8
basophil count
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
83.1
4
76.7
0
1.2
75.4
cancer antigen 19.9 measurement
1
57.8
basophil count
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1S
VGNC:2445
455845
Macaque
microtubule associated protein 1S
719196
Mouse
MGI:2443304
270058
Rat
RGD:1308266
290640
Dog
microtubule associated protein 1S
VGNC:42958
100688192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1S
Macaque
microtubule associated protein 1S
Mouse
Rat
Dog
microtubule associated protein 1S
Publication Statistics
PubMed Score 46.74
PubMed score by year
PubTator Score 24.43
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title