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Tdark
TMEM198
Transmembrane protein 198

Protein Summary
Description
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344458
  • ENSP00000343507
  • ENSG00000188760
  • ENST00000373883
  • ENSP00000362990

Symbol
  • TMEM198A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
cell type or tissue
0.72
tissue sample
0.65
transcription factor
0.63
histone modification site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.68   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.68   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
88.8
creatinine measurement
1
2
2
85.6
electrocardiography
1
1
60
68.6
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
53.3
vital capacity
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
88.8
creatinine measurement
2
85.6
electrocardiography
60
68.6
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
53.3
vital capacity
1
40.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 198
VGNC:2888
743602
Macaque
transmembrane protein 198
704089
Mouse
MGI:2443133
319998
Rat
RGD:2319152
100361928
Horse
transmembrane protein 198
VGNC:24241
100056476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 198
Macaque
transmembrane protein 198
Mouse
Rat
Horse
transmembrane protein 198
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q66K66-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (8)
1 – 8 of 8
TNFAIP1
Tbio
Novelty:  0.04006419
Score:  0.685
Data Source:  STRINGDB
GDAP1
Tbio
Novelty:  0.00682376
Score:  0.641
Data Source:  STRINGDB
RAB39A
Tbio
Family:  Enzyme
Novelty:  0.17719547
Score:  0.641
Data Source:  STRINGDB
DHX33
Tbio
Family:  Enzyme
Novelty:  0.07473852
Score:  0.596
Data Source:  STRINGDB
RAPGEF5
Tbio
Novelty:  0.02449802
Score:  0.581
Data Source:  STRINGDB
CDK14
Tchem
Family:  Kinase
Novelty:  0.02074169
Score:  0.572
Data Source:  STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
Score:  0.472
Data Source:  STRINGDB
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
Score:  0.44
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.68

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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