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Tbio
CEP135
Centrosomal protein of 135 kDa

Protein Summary
Description
Involved in early centriole assembly/duplication/biogenesis/formation/. Required for centriole elongation. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257287
  • ENSP00000257287
  • ENSG00000174799
  • ENST00000422247
  • ENSP00000412799

Symbol
  • CEP4
  • KIAA0635
  • CEP4
  • MCPH8
  • KIAA0635
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
histone modification site profile
0.8
microRNA
0.63
cellular component
0.61
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.09   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.09   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (199)
1 – 10 of 199
TXLNB
Tbio
Novelty: 0.18461538
p_int: 0.99999997
p_ni: 1.6e-8
p_wrong: 1.4e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
WRAP73
Tbio
Novelty: 0.21958871
p_int: 0.999999837
p_ni: 1.63e-7
Score: 0.894
Data Source: BioPlex,STRINGDB
NDEL1
Tbio
Novelty: 0.01425912
p_int: 0.999999588
p_ni: 4.11e-7
Score: 0.37
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.68965517
p_int: 0.999998285
p_ni: 0.000001714
Score: 0.288
Data Source: BioPlex,STRINGDB
MIS18A
Tbio
Novelty: 0.00785124
p_int: 0.999998011
p_ni: 0.000001989
Data Source: BioPlex
CARD9
Tbio
Family: Enzyme
Novelty: 0.00825918
p_int: 0.999942036
p_ni: 0.000057948
p_wrong: 1.6e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
TXLNA
Tbio
Novelty: 0.08198492
p_int: 0.999548924
p_ni: 0.000431618
p_wrong: 0.000019459
Data Source: BioPlex
PLK4
Tchem
Family: Kinase
Novelty: 0.00451442
Score: 0.996
Data Source: STRINGDB
CENPJ
Tbio
Novelty: 0.01558222
Score: 0.996
Data Source: STRINGDB
CEP152
Tbio
Novelty: 0.03983445
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.09

PubMed score by year
PubTator Score  16.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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