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Tdark
LPCAT4
Lysophospholipid acyltransferase LPCAT4

Protein Summary
Description
Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314891
  • ENSP00000317300
  • ENSG00000176454

Symbol
  • AGPAT7
  • AYTL3
  • LPEAT2
  • AYTL3
  • AGPAT7
  • LPEAT2
  • LPAAT-eta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor
0.62
transcription factor binding site profile
0.61
transcription factor perturbation
0.61
cell type or tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1
2
28.3
intelligence
1
1
1
3.5
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
28.3
intelligence
1
3.5
1
3.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidylcholine acyltransferase 4
VGNC:1921
453302
Macaque
lysophosphatidylcholine acyltransferase 4
696388
Mouse
MGI:2138993
99010
Rat
RGD:1311177
296048
Dog
lysophosphatidylcholine acyltransferase 4
VGNC:54323
478238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidylcholine acyltransferase 4
Macaque
lysophosphatidylcholine acyltransferase 4
Mouse
Rat
Dog
lysophosphatidylcholine acyltransferase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q643R3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (90)
1 – 10 of 90
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
p_int: 0.991863423
p_ni: 0.008136577
Score: 0.212
Data Source: BioPlex,STRINGDB
CHRM4
Tclin
Family: GPCR
Novelty: 0.00759817
p_int: 0.865013695
p_ni: 0.134986305
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.844388009
p_ni: 0.155611991
Data Source: BioPlex
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.800110701
p_ni: 0.199889299
Data Source: BioPlex
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.792389053
p_ni: 0.207607149
p_wrong: 0.000003799
Data Source: BioPlex
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.791230052
p_ni: 0.20392462
p_wrong: 0.004845327
Data Source: BioPlex
USP33
Tbio
Family: Enzyme
Novelty: 0.04411285
p_int: 0.771634638
p_ni: 0.173947394
p_wrong: 0.054417967
Score: 0.205
Data Source: BioPlex,STRINGDB
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.762564342
p_ni: 0.237435658
Data Source: BioPlex
GPAT2
Tbio
Family: Enzyme
Novelty: 0.03807198
Score: 0.951
Data Source: STRINGDB
LCLAT1
Tbio
Family: Enzyme
Novelty: 0.03234576
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.78

PubMed score by year
PubTator Score  5.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer