Tbio KANK2 KN motif and ankyrin repeat domain-containing protein 2

Protein Summary

Description

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q63ZY3
• B0I1P4
• Q3KQZ3
• Q6GUF5
• Q9H8S4
• Q9NUP0
• Q9P210

Gene Name

• KANK2

Ensembl ID

• ENST00000586659
• ENSP00000465650
• ENSG00000197256
• ENST00000589359
• ENSP00000468002
• ENST00000589894
• ENSP00000467029

Symbol

• ANKRD25
• KIAA1518
• MXRA3
• SIP
• SIP
• MXRA3
• PPKWH
• NPHS16
• ANKRD25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
co-expressed gene	0.85
ligand (protein) perturbation	0.83
biological process	0.79
microRNA	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0