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Tbio
TNS2
Tensin-2

Protein Summary
Description
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314250
  • ENSP00000319684
  • ENSG00000111077
  • ENST00000314276
  • ENSP00000319756
  • ENST00000379902
  • ENSP00000369232
  • ENST00000546602
  • ENSP00000449363
  • ENST00000552570
  • ENSP00000447021

Symbol
  • KIAA1075
  • TENC1
  • C1TEN
  • TENC1
  • C1-TEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor
0.91
metabolite
0.82
interacting protein
0.81
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.64   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.64   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (54)
1 – 10 of 54
DLC1
Tbio
Family:  Enzyme
Novelty:  0.00819701
Score:  0.993
Data Source:  STRINGDB
STARD13
Tbio
Novelty:  0.00750938
Score:  0.844
Data Source:  STRINGDB
AXL
Tchem
Family:  Kinase
Novelty:  0.00132459
Score:  0.809
Data Source:  STRINGDB
CSK
Tchem
Family:  Kinase
Novelty:  0.00186612
Score:  0.786
Data Source:  STRINGDB
STARD8
Tbio
Novelty:  0.03759193
Score:  0.763
Data Source:  STRINGDB
ARHGAP28
Tdark
Family:  Enzyme
Novelty:  0.33612416
Score:  0.75
Data Source:  STRINGDB
ARHGAP40
Tdark
Family:  Enzyme
Novelty:  4.12645161
Score:  0.739
Data Source:  STRINGDB
ARHGAP18
Tbio
Family:  Enzyme
Novelty:  0.10618156
Score:  0.739
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.641
Data Source:  STRINGDB
CAST
Tbio
Novelty:  0.00099404
Score:  0.628
Data Source:  STRINGDB
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
2
2
40.5
body height
1
1
1
27.2
self reported educational attainment
1
1
1
21.5
BMI-adjusted hip circumference
1
1
1
21.5
electrocardiography
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
40.5
body height
1
27.2
self reported educational attainment
1
21.5
BMI-adjusted hip circumference
1
21.5
electrocardiography
1
17.8
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tensin 2
VGNC:5637
451927
Macaque
tensin 2
700813
Mouse
MGI:2387586
209039
Dog
tensin 2
VGNC:47702
477599
Horse
tensin 2
VGNC:24401
100146672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tensin 2
Macaque
tensin 2
Mouse
Dog
tensin 2
Horse
tensin 2
Publication Statistics
PubMed Score 34.64
PubMed score by year
PubTator Score 16.07
PubTator score by year