Protein Summary
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000314250
- ENSP00000319684
- ENSG00000111077
- ENST00000314276
- ENSP00000319756
- ENST00000379902
- ENSP00000369232
- ENST00000546602
- ENSP00000449363
- ENST00000552570
- ENSP00000447021
- KIAA1075
- TENC1
- C1TEN
- TENC1
- C1-TEN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
transcription factor | 0.91 | ||
metabolite | 0.82 | ||
interacting protein | 0.81 | ||
transcription factor binding site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.92 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 74 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.92 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 74 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0