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Tbio
AFMID
Kynurenine formamidase

Protein Summary
Description
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327898
  • ENSP00000328938
  • ENSG00000183077
  • ENST00000409257
  • ENSP00000386890

Symbol
  • KF
  • FKF
  • KFA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
histone modification site profile
0.77
tissue sample
0.73
biological process
0.66
cell type or tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
9
16
20
99.7
mean corpuscular volume
3
5
5
98.4
red blood cell distribution width
4
6
10
98.1
reticulocyte measurement
3
7
11
95.8
reticulocyte count
7
11
24
95.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
20
99.7
mean corpuscular volume
5
98.4
red blood cell distribution width
10
98.1
reticulocyte measurement
11
95.8
reticulocyte count
24
95.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylformamidase
VGNC:12025
740879
Macaque
arylformamidase
715153
Mouse
MGI:2448704
71562
Rat
RGD:1591143
688283
Horse
arylformamidase
VGNC:15150
100057858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylformamidase
Macaque
arylformamidase
Mouse
Rat
Horse
arylformamidase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q63HM1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (42)
1 – 10 of 42
KMO
Tchem
Family:  Enzyme
Novelty:  0.01469543
Score:  0.985
Data Source:  STRINGDB
TDO2
Tchem
Family:  Enzyme
Novelty:  0.00115832
Score:  0.984
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.976
Data Source:  STRINGDB
KYNU
Tchem
Family:  Enzyme
Novelty:  0.01372383
Score:  0.973
Data Source:  STRINGDB
KYAT3
Tbio
Family:  Enzyme
Novelty:  0.05845124
Score:  0.96
Data Source:  STRINGDB
KYAT1
Tbio
Family:  Enzyme
Novelty:  0.01232903
Score:  0.959
Data Source:  STRINGDB
IDO2
Tchem
Family:  Enzyme
Novelty:  0.01141558
Score:  0.955
Data Source:  STRINGDB
AADAT
Tchem
Family:  Enzyme
Novelty:  0.00678753
Score:  0.955
Data Source:  STRINGDB
PCBD1
Tbio
Family:  Enzyme
Novelty:  0.01564376
Score:  0.949
Data Source:  STRINGDB
IDO1
Tchem
Family:  Enzyme
Novelty:  0.00131229
Score:  0.945
Data Source:  STRINGDB
Publication Statistics
PubMed Score  47.68

PubMed score by year
PubTator Score  11.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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