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Tbio
CD276
CD276 antigen

Protein Summary
Description
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expresse ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318424
  • ENSP00000320058
  • ENSG00000103855
  • ENST00000318443
  • ENSP00000320084
  • ENST00000561213
  • ENSP00000452736
  • ENST00000564751
  • ENSP00000454940

Symbol
  • B7H3
  • B7H3
  • B7-H3
  • B7RP-2
  • 4Ig-B7-H3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.93
protein domain
0.85
microRNA
0.73
biological term
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 823.92   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 799   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 823.92   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 799   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
1
3
72.1
serum gamma-glutamyl transferase measurement
2
2
1
2.4
49.4
smoking status measurement
1
1
1
26.8
insomnia measurement
1
1
0
1
11.6
smoking initiation
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
72.1
serum gamma-glutamyl transferase measurement
1
2.4
49.4
smoking status measurement
1
26.8
insomnia measurement
0
1
11.6
smoking initiation
1
6.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD276 molecule
VGNC:3569
467818
Macaque
CD276 molecule
699877
Mouse
MGI:2183926
102657
Rat
RGD:727815
315716
Dog
CD276 molecule
VGNC:38943
487638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD276 molecule
Macaque
CD276 molecule
Mouse
Rat
Dog
CD276 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5ZPR3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (120)
1 – 10 of 120
CLEC5A
Tbio
Novelty: 0.01710591
p_int: 0.999501187
p_ni: 0.000498813
Score: 0.209
Data Source: BioPlex,STRINGDB
CEACAM21
Tdark
Novelty: 0.46116153
p_int: 0.948376002
p_ni: 0.051623993
p_wrong: 4e-9
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.93806748
p_ni: 0.061932518
p_wrong: 2e-9
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.912191904
p_ni: 0.087808096
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.886048909
p_ni: 0.113951091
Data Source: BioPlex
TNF
Tclin
Novelty: 0.00001457
p_int: 0.873450565
p_ni: 0.126151148
p_wrong: 0.000398288
Score: 0.677
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.824854319
p_ni: 0.174646833
p_wrong: 0.000498847
Score: 0.456
Data Source: BioPlex,STRINGDB
TMX1
Tbio
Novelty: 0.03444237
p_int: 0.814186329
p_ni: 0.18581367
p_wrong: 1e-9
Data Source: BioPlex
LILRB4
Tbio
Novelty: 0.01443658
p_int: 0.784085087
p_ni: 0.215729594
p_wrong: 0.000185319
Score: 0.426
Data Source: BioPlex,STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.816
Data Source: STRINGDB
Publication Statistics
PubMed Score  823.92

PubMed score by year
PubTator Score  177.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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