Tclin ANO1 Anoctamin-1

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium-dependent Chloride Channel (Ca-clc) Family / Anoctamin-1

Protein Summary

Description

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Uniprot Accession IDs

• Q5XXA6
• A8KAM3
• Q8IYY8
• Q8N7V3

Gene Name

• ANO1

Ensembl ID

• ENST00000316296
• ENSP00000319477
• ENSG00000131620
• ENST00000355303
• ENSP00000347454
• ENST00000530676
• ENSP00000435797

Symbol

• DOG1
• ORAOV2
• TAOS2
• TMEM16A
• DOG1
• TAOS2
• ORAOV2
• TMEM16A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
gene perturbation	0.87
cellular component	0.8
biological term	0.78
kinase perturbation	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.53   (req: < 5)

Gene RIFs: 140   (req: <= 3)

Antibodies: 1224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.53   (req: >= 5)

Gene RIFs: 140   (req: > 3)

Antibodies: 1224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

crofelemer

ANO1Tclin IC

INHIBITOR IC50: 5.18708658

Active Ligands (12)

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1 – 10 of 12

crofelemer

ANO1Tclin IC

IC50: 5.19000006

CHEMBL2047089

ANO1Tclin IC

IC50: 5.2

CHEMBL2047093

ANO1Tclin IC

IC50: 5.31

CHEMBL2047098

ANO1Tclin IC

IC50: 5.5

CHEMBL2047083

ANO1Tclin IC

IC50: 5.48

CHEMBL2047095

ANO1Tclin IC

IC50: 5.55

CHEMBL2047097

ANO1Tclin IC

IC50: 5.5

CHEMBL2047087

ANO1Tclin IC

IC50: 5.05

CHEMBL2046973

ANO1Tclin IC

IC50: 5.23

CHEMBL2047099

ANO1Tclin IC

IC50: 5.28

Pathways (3)

Reactome (3)

Ion channel transport (R-HSA-983712)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Stimuli-sensing channels	102 targets	R-HSA-2672351
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Ion channel transport	179 targets	R-HSA-983712
Stimuli-sensing channels	102 targets	R-HSA-2672351
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (21)

Functions (6)

Components (5)

Processes (10)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
calcium activated cation channel activity	Inferred from Direct Assay (IDA)	UniProtKB
intracellular calcium activated chloride channel activity	Inferred from Direct Assay (IDA)	UniProtKB
chloride channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
iodide transmembrane transporter activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
voltage-gated chloride channel activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein dimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (130)

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1 – 10 of 130

• See Interactions on String-DB

CFTR

Tclin

Family: IC

Novelty: 0.00015058

Score: 0.911

Data Source: STRINGDB

BEST2

Tbio

Family: IC

Novelty: 0.01308106

Score: 0.866

Data Source: STRINGDB

BEST3

Tbio

Family: IC

Novelty: 0.01351175

Score: 0.846

Data Source: STRINGDB

BEST4

Tbio

Family: IC

Novelty: 0.02842589

Score: 0.845

Data Source: STRINGDB

BEST1

Tbio

Family: IC

Novelty: 0.00188825

Score: 0.844

Data Source: STRINGDB

KIT

Tclin

Family: Kinase

Novelty: 0.00013951

Score: 0.799

Data Source: STRINGDB

CLCN2

Tclin

Family: IC

Novelty: 0.00818572

Score: 0.777

Data Source: STRINGDB

CLCNKB

Tchem

Family: IC

Novelty: 0.0113915

Score: 0.772

Data Source: STRINGDB

CLCNKA

Tchem

Family: IC

Novelty: 0.026414

Score: 0.768

Data Source: STRINGDB

CD34

Tbio

Novelty: 0.00007032

Score: 0.736

Data Source: STRINGDB

Publication Statistics

PubMed Score  523.53

PubMed score by year

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PubTator Score  328

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHH

1-70

KRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGL

70-140

ELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVA

140-210

EHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAA

210-280

YPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGI

280-350

IVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA

350-420

ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQ

420-490

RVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNI

490-560

RVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKG

560-630

RFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSP

630-700

PDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVT

700-770

ELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV

770-840

SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDW

840-910

VIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHA

910-980

YHGGVL

980-986

MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL

Find similar targets by:

Uniprot Keyword

Alternative splicing
Calcium
Cell membrane
Chloride
Chloride channel
Complete proteome
Cytoplasm
Developmental protein
Glycoprotein
Ion channel