Protein Classes
Protein Summary
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
- ENST00000316296
- ENSP00000319477
- ENSG00000131620
- ENST00000355303
- ENSP00000347454
- ENST00000530676
- ENSP00000435797
- DOG1
- ORAOV2
- TAOS2
- TMEM16A
- DOG1
- TAOS2
- ORAOV2
- TMEM16A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
gene perturbation | 0.87 | ||
cellular component | 0.8 | ||
biological term | 0.78 | ||
kinase perturbation | 0.71 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 779.37 (req: < 5)
Gene RIFs: 140 (req: <= 3)
Antibodies: 1224 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 779.37 (req: >= 5)
Gene RIFs: 140 (req: > 3)
Antibodies: 1224 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 12
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (12)
1 – 10 of 12
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 1 | 2 | 62.6 | |||||
diastolic blood pressure | 1 | 1 | 1 | 56.1 | |||||
basophil count | 2 | 1 | 2 | 45.6 | |||||
aortic root size | 1 | 1 | 1 | 30.1 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 19.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 62.6 | |||||
diastolic blood pressure | 1 | 56.1 | |||||
basophil count | 2 | 45.6 | |||||
aortic root size | 1 | 30.1 | |||||
eosinophil percentage of leukocytes | 1 | 19.2 | |||||
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
Transport of small molecules | ||||
Gene Ontology Terms (21)
Functions (6)
Components (5)
Processes (10)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (130)
1 – 10 of 130
CFTR
Family: IC
Novelty: 0.00012639
Score: 0.911
Data Source: STRINGDB
BEST2
Family: IC
Novelty: 0.03182837
Score: 0.866
Data Source: STRINGDB
BEST3
Family: IC
Novelty: 0.03481733
Score: 0.846
Data Source: STRINGDB
BEST4
Family: IC
Novelty: 0.06102944
Score: 0.845
Data Source: STRINGDB
BEST1
Family: IC
Novelty: 0.0026324
Score: 0.844
Data Source: STRINGDB
KIT
Family: Kinase
Novelty: 0.00011237
Score: 0.799
Data Source: STRINGDB
CLCN2
Family: IC
Novelty: 0.00838393
Score: 0.777
Data Source: STRINGDB
CLCNKB
Family: IC
Novelty: 0.00982208
Score: 0.772
Data Source: STRINGDB
CLCNKA
Family: IC
Novelty: 0.02129502
Score: 0.768
Data Source: STRINGDB
CD34
Novelty: 0.00005468
Score: 0.736
Data Source: STRINGDB
Publication Statistics
PubMed Score 779.37
PubMed score by year
PubTator Score 328
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait