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Tbio
FBXW10
F-box/WD repeat-containing protein 10

Protein Summary
Description
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301938
  • ENSP00000306937
  • ENSG00000171931
  • ENST00000308799
  • ENSP00000310382
  • ENST00000395665
  • ENSP00000379025

Symbol
  • HREP
  • Fbw10
  • SM25H2
  • SM2SH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.61
cell line
0.58
tissue sample
0.53
gene perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (317)
1 – 10 of 317
SKP1
Tbio
Family: Enzyme
Novelty: 0.00209659
Score: 0.973
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00339576
Score: 0.969
Data Source: STRINGDB
FBXO41
Tdark
Novelty: 0.19758507
Score: 0.962
Data Source: STRINGDB
FBXL4
Tbio
Novelty: 0.06259235
Score: 0.962
Data Source: STRINGDB
FBXW9
Tdark
Novelty: 1
Score: 0.956
Data Source: STRINGDB
HECW2
Tbio
Family: Enzyme
Novelty: 0.11984591
Score: 0.955
Data Source: STRINGDB
FBXW4
Tbio
Novelty: 0.0652799
Score: 0.952
Data Source: STRINGDB
FBXW5
Tbio
Novelty: 0.24030104
Score: 0.95
Data Source: STRINGDB
FBXL22
Tdark
Novelty: 2.88157895
Score: 0.95
Data Source: STRINGDB
FBXL15
Tbio
Novelty: 0.00344491
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.06

PubMed score by year
PubTator Score  2.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer