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Tbio
FBXO31
F-box only protein 31

Protein Summary
Description
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311635
  • ENSP00000310841
  • ENSG00000103264

Symbol
  • FBX14
  • FBX31
  • FBX14
  • Fbx31
  • MRT45
  • FBXO14
  • pp2386
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.95
small molecule perturbation
0.83
transcription factor perturbation
0.8
microRNA
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.47   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.47   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mood instability measurement
1
1
0
6.6
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mood instability measurement
0
6.6
33.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 31
VGNC:5767
454297
Macaque
F-box protein 31
695313
Mouse
MGI:1354708
76454
Rat
RGD:1561069
498959
Dog
F-box protein 31
VGNC:40773
479620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 31
Macaque
F-box protein 31
Mouse
Rat
Dog
F-box protein 31
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5XUX0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (328)
1 – 10 of 328
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999999892
p_ni: 9.4e-8
p_wrong: 1.4e-8
Score: 0.962
Data Source: BioPlex,STRINGDB
FAM98A
Tdark
Novelty: 0.30067413
p_int: 0.999997563
p_wrong: 0.000002437
Score: 0.403
Data Source: BioPlex,STRINGDB
FBXO4
Tbio
Novelty: 0.06891705
Score: 0.977
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.966
Data Source: STRINGDB
FBXW8
Tbio
Novelty: 0.06697145
Score: 0.952
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.944
Data Source: STRINGDB
FBXO21
Tbio
Novelty: 0.2186203
Score: 0.934
Data Source: STRINGDB
FBXL19
Tbio
Novelty: 0.07526966
Score: 0.933
Data Source: STRINGDB
KLHL41
Tbio
Novelty: 0.03973182
Score: 0.933
Data Source: STRINGDB
ASB14
Tdark
Novelty: 1.75017246
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.47

PubMed score by year
PubTator Score  10.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer