Tbio CARD17 Caspase recruitment domain-containing protein 17

Protein Summary

Description

Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.

Uniprot Accession IDs

• Q5XLA6

Gene Name

• CARD17

Ensembl ID

• ENST00000375707
• ENSP00000364859
• ENSG00000255221

Symbol

• INCA
• INCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	1
cell line	0.54
tissue sample	0.48
virus perturbation	0.41
cellular component	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0