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Tbio
MIC13
MICOS complex subunit MIC13

Protein Summary
Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309324
  • ENSP00000309561
  • ENSG00000174917

Symbol
  • C19orf70
  • QIL1
  • P117
  • QIL1
  • MIC13
  • C19orf70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
2
2
93.7
mean corpuscular hemoglobin concentration
1
1
1
75.2
red blood cell distribution width
2
2
2
66.6
mean corpuscular volume
1
1
1
59.6
mean reticulocyte volume
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
2
93.7
mean corpuscular hemoglobin concentration
1
75.2
red blood cell distribution width
2
66.6
mean corpuscular volume
1
59.6
mean reticulocyte volume
1
52
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5XKP0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (55)
1 – 10 of 55
APOOL
Tbio
Novelty:  0.08233023
Score:  0.978
Data Source:  STRINGDB
SAMM50
Tbio
Novelty:  0.00553631
Score:  0.976
Data Source:  STRINGDB
APOO
Tbio
Novelty:  0.04964756
Score:  0.976
Data Source:  STRINGDB
MTX2
Tbio
Novelty:  0.02047483
Score:  0.974
Data Source:  STRINGDB
CHCHD3
Tbio
Novelty:  0.05341939
Score:  0.971
Data Source:  STRINGDB
CHCHD6
Tbio
Novelty:  0.12379343
Score:  0.971
Data Source:  STRINGDB
MINOS1
Tdark
Novelty:  0.40437095
Score:  0.97
Data Source:  STRINGDB
DNAJC11
Tbio
Novelty:  0.31080011
Score:  0.968
Data Source:  STRINGDB
IMMT
Tbio
Novelty:  0.00260309
Score:  0.963
Data Source:  STRINGDB
MTX1
Tbio
Novelty:  0.02350764
Score:  0.962
Data Source:  STRINGDB
Publication Statistics
PubMed Score  29.76

PubMed score by year
PubTator Score  10.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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