Tbio TENT4A Non-canonical poly(A) RNA polymerase PAPD7

Protein Summary

Description

Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q5XG87
• A8K1E2
• M1JCE6
• O43289
• Q17RZ1
• Q9Y6C1

Gene Name

• TENT4A

Ensembl ID

• ENST00000631941
• ENSP00000488642
• ENSG00000112941

Symbol

• PAPD7
• POLS
• TRF4
• LAK1
• POLK
• POLS
• TRF4
• LAK-1
• PAPD7
• TRF41
• TRF4-1
• TUTASE5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
virus perturbation	0.88
transcription factor	0.82
transcription factor binding site profile	0.77
molecular function	0.67

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Non-canonical Poly(a) Rna Polymerase Papd7

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Non-canonical Poly(a) Rna Polymerase Papd7

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Non-canonical Poly(a) Rna Polymerase Papd7

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Non-canonical Poly(a) Rna Polymerase Papd7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.66   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.66   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0