You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TENT4A
Non-canonical poly(A) RNA polymerase PAPD7

Protein Classes
Protein Summary
Description
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000631941
  • ENSP00000488642
  • ENSG00000112941

Symbol
  • PAPD7
  • POLS
  • TRF4
  • LAK1
  • POLK
  • POLS
  • TRF4
  • LAK-1
  • PAPD7
  • TRF41
  • TRF4-1
  • TUTASE5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.88
transcription factor
0.82
transcription factor binding site profile
0.77
molecular function
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.96   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.96   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
30.2
sphingolipid measurement
1
1
1
24.5
1
1
0
1.1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
30.2
sphingolipid measurement
1
24.5
0
1.1
12.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
terminal nucleotidyltransferase 4A
VGNC:13560
461712
Macaque
poly(A) RNA polymerase D7, non-canonical
713853
Mouse
MGI:2682295
210106
Rat
RGD:1307356
306672
Dog
terminal nucleotidyltransferase 4A
VGNC:54106
488057
Species
Name
OMA
EggNOG
Inparanoid
Chimp
terminal nucleotidyltransferase 4A
Macaque
poly(A) RNA polymerase D7, non-canonical
Mouse
Rat
Dog
terminal nucleotidyltransferase 4A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5XG87-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Protein-Protein Interactions (183)
1 – 10 of 183
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.990909237
p_ni:  9.43e-7
p_wrong:  0.00908982
Score:  0.25
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.945823836
p_ni:  0.054176164
Score:  0.261
Data Source:  BioPlex,STRINGDB
ZCCHC7
Tbio
Novelty:  0.01655453
Score:  0.95
Data Source:  STRINGDB
MTREX
Tbio
Novelty:  0.01358024
Score:  0.939
Data Source:  STRINGDB
QKI
Tbio
Novelty:  0.00966983
Score:  0.922
Data Source:  STRINGDB
KDM7A
Tchem
Family:  Epigenetic
Novelty:  0.04113733
Score:  0.909
Data Source:  STRINGDB
TLN1
Tbio
Novelty:  0.00803981
Score:  0.906
Data Source:  STRINGDB
AGGF1
Tbio
Novelty:  0.02757407
Score:  0.905
Data Source:  STRINGDB
AP3B1
Tbio
Novelty:  0.03117931
Score:  0.905
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.905
Data Source:  STRINGDB
Publication Statistics
PubMed Score  209.96

PubMed score by year
PubTator Score  21.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer