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Tbio
CST9
Cystatin-9

Protein Summary
Description
May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation (PubMed:12535658). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243). The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376971
  • ENSP00000366170
  • ENSG00000173335

Symbol
  • CLM
  • CTES7A
  • CLM
  • CTES7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cell line
0.66
microRNA
0.51
PubMedID
0.5
tissue
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
acute coronary syndrome
1
1
1
77.9
age at onset
1
1
0
5.7
3.4
1
1
0
5.7
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
acute coronary syndrome
1
77.9
age at onset
0
5.7
3.4
0
5.7
3.4
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin 9
VGNC:13841
469903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5W186-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (20)
1 – 10 of 20
ITGA4
Tclin
Novelty:  0.00197607
p_int:  0.998446921
p_ni:  0.001553079
Score:  0.237
Data Source:  BioPlex,STRINGDB
PCP2
Tdark
Novelty:  0.05083955
p_int:  0.98617443
p_ni:  0.013573621
p_wrong:  0.000251949
Score:  0.332
Data Source:  BioPlex,STRINGDB
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.885075521
p_ni:  0.114924303
p_wrong:  1.76e-7
Score:  0.696
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.855545818
p_ni:  0.144454182
Score:  0.69
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
Score:  0.731
Data Source:  STRINGDB
CST4
Tbio
Novelty:  0.00773554
Score:  0.725
Data Source:  STRINGDB
CST7
Tbio
Novelty:  0.03651959
Score:  0.713
Data Source:  STRINGDB
CST8
Tbio
Novelty:  0.02316886
Score:  0.693
Data Source:  STRINGDB
ACSS1
Tbio
Family:  Enzyme
Novelty:  0.02003886
Score:  0.626
Data Source:  STRINGDB
CST11
Tbio
Novelty:  0.0327324
Score:  0.595
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.48

PubMed score by year
PubTator Score  15.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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