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Tbio
ZDHHC20
Palmitoyltransferase ZDHHC20

Protein Summary
Description
Catalyzes palmitoylation of Cys residues on target proteins (PubMed:27153536, PubMed:29326245). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320220
  • ENSP00000313583
  • ENSG00000180776
  • ENST00000382466
  • ENSP00000371905
  • ENST00000400590
  • ENSP00000383433
  • ENST00000415724
  • ENSP00000401232

Symbol
  • DHHC20
  • DHHC-20
  • 4933421L13Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
histone modification site profile
0.66
tissue sample
0.64
small molecule perturbation
0.63
microRNA
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.35   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.35   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 20
VGNC:7838
452474
Macaque
zinc finger DHHC-type containing 20
705802
Mouse
MGI:1923215
75965
Rat
RGD:1305755
305923
Dog
zinc finger DHHC-type containing 20
VGNC:48586
486045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 20
Macaque
zinc finger DHHC-type containing 20
Mouse
Rat
Dog
zinc finger DHHC-type containing 20
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5W0Z9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (21)
1 – 10 of 21
BTC
Tbio
Novelty: 0.00673076
p_int: 0.999500395
p_ni: 0.000007095
p_wrong: 0.00049251
Data Source: BioPlex
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.857265817
p_ni: 0.000005589
p_wrong: 0.142728594
Score: 0.221
Data Source: BioPlex,STRINGDB
MICU2
Tbio
Novelty: 0.04146208
Score: 0.735
Data Source: STRINGDB
DDX6
Tbio
Family: Enzyme
Novelty: 0.01032357
Score: 0.675
Data Source: STRINGDB
LYPLA2
Tchem
Family: Enzyme
Novelty: 0.05436006
Score: 0.595
Data Source: STRINGDB
ZFAND6
Tbio
Novelty: 0.08904571
Score: 0.576
Data Source: STRINGDB
ZNF609
Tdark
Novelty: 0.06635612
Score: 0.573
Data Source: STRINGDB
LYPLA1
Tchem
Family: Enzyme
Novelty: 0.01217068
Score: 0.561
Data Source: STRINGDB
ZMYM5
Tdark
Novelty: 0.15229851
Score: 0.548
Data Source: STRINGDB
PRRC2C
Tbio
Novelty: 0.25128003
Score: 0.541
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.35

PubMed score by year
PubTator Score  2.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer