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Tbio
RRAGB
Ras-related GTP-binding protein B

Protein Summary
Description
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-bindin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262850
  • ENSP00000262850
  • ENSG00000083750
  • ENST00000374941
  • ENSP00000364077

Symbol
  • RAGB
  • bA465E19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
virus perturbation
0.64
histone modification site profile
0.59
small molecule perturbation
0.54
tissue sample
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding B
VGNC:8332
473629
Macaque
Ras related GTP binding B
704260
Mouse
MGI:3038613
245670
Rat
RGD:11422614
108348096
Dog
Ras related GTP binding B
VGNC:54187
491907
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding B
Macaque
Ras related GTP binding B
Mouse
Rat
Dog
Ras related GTP binding B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VZM2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (54)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (113)
1 – 10 of 113
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.999988238
p_ni: 0.000011762
Score: 0.999
Data Source: BioPlex,STRINGDB
LAMTOR3
Tbio
Novelty: 0.050644
p_int: 0.999967103
p_ni: 0.000032897
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty: 0.24218646
p_int: 0.999904647
p_ni: 0.000095353
Score: 0.999
Data Source: BioPlex,STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
p_int: 0.998789392
p_ni: 0.001207518
p_wrong: 0.00000309
Data Source: BioPlex
BLVRA
Tbio
Family: Enzyme
Novelty: 0.00526407
p_int: 0.998348086
p_ni: 0.001599869
p_wrong: 0.000052045
Score: 0.163
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.99776992
p_ni: 0.002227924
p_wrong: 0.000002155
Score: 0.514
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.997187147
p_ni: 0.002811551
p_wrong: 0.000001302
Score: 0.211
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.996124543
p_ni: 0.003875342
p_wrong: 1.16e-7
Data Source: BioPlex
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.993154654
p_ni: 0.004821317
p_wrong: 0.002024029
Score: 0.159
Data Source: BioPlex,STRINGDB
CDH13
Tbio
Novelty: 0.00389516
p_int: 0.968779466
p_ni: 0.028430643
p_wrong: 0.002789892
Score: 0.248
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  40.11

PubMed score by year
PubTator Score  12.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer