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Tbio
DENND4C
DENN domain-containing protein 4C

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434457
  • ENSP00000473469
  • ENSG00000137145
  • ENST00000602925
  • ENSP00000473565

Symbol
  • C9orf55
  • C9orf55B
  • C9orf55
  • C9orf55B
  • RAB10GEF
  • bA513M16.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
drug perturbation
0.71
kinase perturbation
0.71
microRNA
0.71
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
36.4
high density lipoprotein cholesterol measurement
1
1
1
29.4
HMG CoA reductase inhibitor use measurement
1
1
1
15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
36.4
high density lipoprotein cholesterol measurement
1
29.4
HMG CoA reductase inhibitor use measurement
1
15
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914769
329877
Rat
RGD:1308489
313340
Dog
DENN domain containing 4C
VGNC:39892
100856373
Horse
DENN domain containing 4C
VGNC:17126
100052312
Opossum
DENN domain containing 4C
100010079
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
DENN domain containing 4C
Horse
DENN domain containing 4C
Opossum
DENN domain containing 4C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VZ89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (30)
1 – 10 of 30
TGM2
Tchem
Family: Enzyme
Novelty: 0.0005293
p_int: 0.875994595
p_ni: 0.109552516
p_wrong: 0.014452889
Data Source: BioPlex
RAB10
Tbio
Family: Enzyme
Novelty: 0.00870713
Score: 0.974
Data Source: Reactome,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
Score: 0.905
Data Source: Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.903
Data Source: Reactome,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
Score: 0.901
Data Source: Reactome,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.9
Data Source: Reactome,STRINGDB
TBC1D4
Tbio
Novelty: 0.00549202
Score: 0.573
Data Source: STRINGDB
VPS26B
Tdark
Novelty: 0.25702869
Score: 0.551
Data Source: STRINGDB
VPS26A
Tbio
Novelty: 0.01804654
Score: 0.544
Data Source: STRINGDB
FAM84B
Tbio
Novelty: 0.10702561
Score: 0.539
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.74

PubMed score by year
PubTator Score  0.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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