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Tdark
NXNL2
Nucleoredoxin-like protein 2

Protein Summary
Description
May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375854
  • ENSP00000365014
  • ENSG00000130045
  • ENST00000375855
  • ENSP00000365015

Symbol
  • C9orf121
  • RDCVF2
  • RdCVF2L
  • C9orf121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
histone modification site profile
0.63
tissue sample
0.6
cellular component
0.5
tissue
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoredoxin like 2
VGNC:53287
464578
Macaque
nucleoredoxin like 2 [Source:HGNC Symbol;Acc:HGNC:30482]
Mouse
MGI:1922374
75124
Rat
RGD:1594820
689232
Horse
nucleoredoxin like 2
VGNC:20986
100054953
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoredoxin like 2
Macaque
nucleoredoxin like 2 [Source:HGNC Symbol;Acc:HGNC:30482]
Mouse
Rat
Horse
nucleoredoxin like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VZ03-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (22)
1 – 10 of 22
USP19
Tbio
Family: Enzyme
Novelty: 0.04078253
p_int: 0.989147228
p_ni: 0.010852772
Data Source: BioPlex
PDCL
Tbio
Novelty: 0.00317454
p_int: 0.806551877
p_ni: 0.193437323
p_wrong: 0.0000108
Data Source: BioPlex
CCDC66
Tbio
Novelty: 0.09165151
Score: 0.701
Data Source: STRINGDB
REEP6
Tbio
Novelty: 0.10645981
Score: 0.591
Data Source: STRINGDB
C8orf37
Tbio
Novelty: 0.06339955
Score: 0.577
Data Source: STRINGDB
ATXN10
Tbio
Novelty: 0.01008505
Score: 0.576
Data Source: STRINGDB
TNNI1
Tbio
Novelty: 0.01639536
Score: 0.555
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.524
Data Source: STRINGDB
SH3BGR
Tbio
Novelty: 0.19912265
Score: 0.511
Data Source: STRINGDB
ARR3
Tbio
Novelty: 0.00575939
Score: 0.511
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.61

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer