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Tbio
TUT7
Terminal uridylyltransferase 7

Protein Summary
Description
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridyla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375960
  • ENSP00000365127
  • ENSG00000083223
  • ENST00000375963
  • ENSP00000365130

Symbol
  • HS2
  • KIAA1711
  • ZCCHC6
  • PAPD6
  • TENT3B
  • ZCCHC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.91
transcription factor binding site profile
0.87
kinase perturbation
0.76
transcription factor
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
65.1
testosterone measurement
1
1
1
37
reticulocyte measurement
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
65.1
testosterone measurement
1
37
reticulocyte measurement
1
15.7
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (68)
1 – 10 of 68
CCDC59
Tbio
Novelty: 0.05894885
p_int: 0.99999986
p_ni: 1.39e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.999804203
p_ni: 0.000195797
Score: 0.158
Data Source: BioPlex,STRINGDB
RPS13
Tbio
Novelty: 0.0019983
p_int: 0.997178793
p_ni: 0.002821207
Data Source: BioPlex
H1FNT
Tdark
Novelty: 0.05593238
p_int: 0.994450633
p_ni: 0.005549357
p_wrong: 1e-8
Data Source: BioPlex
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.944529984
p_ni: 0.055469974
p_wrong: 4.3e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.897699006
p_ni: 0.102300163
p_wrong: 8.31e-7
Data Source: BioPlex
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.877046928
p_ni: 0.122953072
Score: 0.152
Data Source: BioPlex,STRINGDB
ZNF512
Tbio
Family: TF
Novelty: 0.08783629
p_int: 0.848850514
p_ni: 0.151149483
p_wrong: 3e-9
Score: 0.155
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.828692269
p_ni: 0.171307603
p_wrong: 1.29e-7
Data Source: BioPlex
PABPC1
Tbio
Novelty: 0.00197523
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.14

PubMed score by year
PubTator Score  17.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer