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Tbio
PEAR1
Platelet endothelial aggregation receptor 1

Protein Summary
Description
When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292357
  • ENSP00000292357
  • ENSG00000187800
  • ENST00000338302
  • ENSP00000344465

Symbol
  • MEGF12
  • JEDI
  • MEGF12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
protein domain
0.58
tissue sample
0.57
microRNA
0.47
tissue
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.5   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.5   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
SHC2
Tbio
Novelty:  0.00219395
Score:  0.756
Data Source:  STRINGDB
LRRC71
Tdark
Novelty:  3.35475297
Score:  0.747
Data Source:  STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
Score:  0.724
Data Source:  STRINGDB
IQGAP3
Tbio
Family:  Enzyme
Novelty:  0.05874747
Score:  0.679
Data Source:  STRINGDB
SPEG
Tbio
Family:  Kinase
Novelty:  0.01666376
Score:  0.674
Data Source:  STRINGDB
GULP1
Tbio
Novelty:  0.01367525
Score:  0.662
Data Source:  STRINGDB
ETV3L
Tdark
Family:  TF
Novelty:  0.7901219
Score:  0.66
Data Source:  STRINGDB
PCLO
Tbio
Novelty:  0.00918397
Score:  0.632
Data Source:  STRINGDB
ESYT1
Tbio
Novelty:  0.03069611
Score:  0.626
Data Source:  STRINGDB
RBCK1
Tbio
Novelty:  0.02760333
Score:  0.626
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
4
9
98.4
platelet count
4
5
7
90.9
platelet crit
1
2
2
82.4
lymphocyte count
2
2
2
70.4
body height
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
98.4
platelet count
7
90.9
platelet crit
2
82.4
lymphocyte count
2
70.4
body height
1
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet endothelial aggregation receptor 1
VGNC:1443
457409
Mouse
MGI:1920432
73182
Rat
RGD:1305653
295293
Dog
platelet endothelial aggregation receptor 1
VGNC:44408
490403
Horse
platelet endothelial aggregation receptor 1
VGNC:21298
100064623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet endothelial aggregation receptor 1
Mouse
Rat
Dog
platelet endothelial aggregation receptor 1
Horse
platelet endothelial aggregation receptor 1
Publication Statistics
PubMed Score 51.50
PubMed score by year
PubTator Score 44.43
PubTator score by year
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Related Publications
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PMID
Year
Title