Tbio PEAR1 Platelet endothelial aggregation receptor 1

Protein Summary

Description

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5VY43
• Q8TEK2
• hPEAR1

Gene Name

• PEAR1

Ensembl ID

• ENST00000292357
• ENSP00000292357
• ENSG00000187800
• ENST00000338302
• ENSP00000344465

Symbol

• MEGF12
• JEDI
• MEGF12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.68
protein domain	0.58
tissue sample	0.57
microRNA	0.47
tissue	0.45

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Platelet Endothelial Aggregation Receptor 1

Protein / Receptor / Platelet Endothelial Aggregation Receptor 1

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Platelet Endothelial Aggregation Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.96   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.96   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0