Protein Summary
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
- ENST00000404190
- ENSP00000383900
- ENSG00000204021
- LIPL2
- LIPL2
- bA186O14.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.65 | ||
protein domain | 0.58 | ||
tissue | 0.54 | ||
cell line | 0.41 | ||
phenotype | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.2 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 99 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.2 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 99 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (25)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lipase family member K | VGNC:7850 | 737986 | |||||
Macaque | lipase family member K | 693627 | ||||||
Mouse | MGI:2679259 | 240633 | ||||||
Rat | RGD:1309724 | 294094 | ||||||
Dog | lipase family member K | VGNC:52938 | 486465 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lipase family member K | |||||
Macaque | lipase family member K | |||||
Mouse | ||||||
Rat | ||||||
Dog | lipase family member K | |||||
Publication Statistics
PubMed Score 9.20
PubMed score by year
PubTator Score 3.09
PubTator score by year
Related Publications
Text Mined References (2)
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