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Tbio
LIPK
Lipase member K

Protein Summary
Description
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404190
  • ENSP00000383900
  • ENSG00000204021

Symbol
  • LIPL2
  • LIPL2
  • bA186O14.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
protein domain
0.58
tissue
0.54
cell line
0.41
phenotype
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.2   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.2   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
GLYATL2
Tbio
Family:  Enzyme
Novelty:  0.28659241
Score:  0.734
Data Source:  STRINGDB
ACSM3
Tbio
Family:  Enzyme
Novelty:  0.02440917
Score:  0.707
Data Source:  STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.656
Data Source:  STRINGDB
ABCC11
Tbio
Family:  Transporter
Novelty:  0.01382192
Score:  0.62
Data Source:  STRINGDB
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
Score:  0.546
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.544
Data Source:  STRINGDB
CH25H
Tbio
Family:  Enzyme
Novelty:  0.01620877
Score:  0.53
Data Source:  STRINGDB
MINPP1
Tbio
Family:  Enzyme
Novelty:  0.02584444
Score:  0.518
Data Source:  STRINGDB
ANKRD22
Tbio
Novelty:  0.28856283
Score:  0.517
Data Source:  STRINGDB
FRRS1L
Tbio
Novelty:  0.00607449
Score:  0.505
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase family member K
VGNC:7850
737986
Macaque
lipase family member K
693627
Mouse
MGI:2679259
240633
Rat
RGD:1309724
294094
Dog
lipase family member K
VGNC:52938
486465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase family member K
Macaque
lipase family member K
Mouse
Rat
Dog
lipase family member K
Publication Statistics
PubMed Score 9.20
PubMed score by year
PubTator Score 3.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title