You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LIPN
Lipase member N

Protein Summary
Description
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404459
  • ENSP00000383923
  • ENSG00000204020

Symbol
  • LIPL4
  • LI4
  • ARCI8
  • LIPL4
  • bA186O14.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
protein domain
0.58
tissue
0.42
cell line
0.38
biological term
0.33


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 751.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 751.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase family member N
VGNC:7852
466144
Macaque
lipase family member N
693761
Mouse
MGI:1917416
70166
Rat
RGD:1560354
499345
Horse
lipase family member N
VGNC:19689
100071663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase family member N
Macaque
lipase family member N
Mouse
Rat
Horse
lipase family member N
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VXI9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (40)
1 – 10 of 40
PCSK5
Tchem
Family:  Enzyme
Novelty:  0.00070772
Score:  0.893
Data Source:  STRINGDB
CYP4F22
Tbio
Novelty:  0.01907586
Score:  0.878
Data Source:  STRINGDB
SP6
Tbio
Family:  TF
Novelty:  0.00201789
Score:  0.86
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.836
Data Source:  STRINGDB
PNPLA1
Tbio
Family:  Enzyme
Novelty:  0.03127922
Score:  0.797
Data Source:  STRINGDB
ACRV1
Tbio
Novelty:  0.00291978
Score:  0.789
Data Source:  STRINGDB
SP9
Tdark
Family:  TF
Novelty:  0.00476397
Score:  0.789
Data Source:  STRINGDB
MARVELD1
Tbio
Novelty:  0.01687447
Score:  0.789
Data Source:  STRINGDB
NIPAL4
Tbio
Novelty:  0.05110099
Score:  0.78
Data Source:  STRINGDB
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
Score:  0.761
Data Source:  STRINGDB
Publication Statistics
PubMed Score  751.78

PubMed score by year
PubTator Score  399.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer